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Review APA guidelines for the body of an APA-style paper.

FirstPage-Template

Beginning at the top of a new page, the main body of the research paper follows the abstract and precedes the References page. Comprised of the introduction, method, results, and discussion subsections, the main body acts as the third major section of the document and typically begins on the third page of the paper.

General Format

Like the rest of the paper, the pages of the main body should be double-spaced and typed in Times New Roman, 12 pt. The margins are set at 1” on all sides. While the running head is flush with the upper left-hand corner of every page, the page number is flush with the upper right-hand corner of every page. Note that all letters of the running head should be capitalized and should not exceed 50 characters, including punctuation, letters, and spaces.

The full title of the paper is centered directly above the introduction with no extra space between the title and the first paragraph. Avoid formatting the title with bold, italics, underlining, or quotation marks. The first letter of each major word in the title should be capitalized. Unlike other sections of the main body, the introduction does not require a heading or label.

When writing each paragraph, note that the APA recommends using two spaces after sentences that end in a period; however, sentences that end in other punctuation marks may be followed by a single space.

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Home » Research Paper – Structure, Examples and Writing Guide

Research Paper – Structure, Examples and Writing Guide

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Research Paper

Research Paper

Definition:

Research Paper is a written document that presents the author’s original research, analysis, and interpretation of a specific topic or issue.

It is typically based on Empirical Evidence, and may involve qualitative or quantitative research methods, or a combination of both. The purpose of a research paper is to contribute new knowledge or insights to a particular field of study, and to demonstrate the author’s understanding of the existing literature and theories related to the topic.

Structure of Research Paper

The structure of a research paper typically follows a standard format, consisting of several sections that convey specific information about the research study. The following is a detailed explanation of the structure of a research paper:

The title page contains the title of the paper, the name(s) of the author(s), and the affiliation(s) of the author(s). It also includes the date of submission and possibly, the name of the journal or conference where the paper is to be published.

The abstract is a brief summary of the research paper, typically ranging from 100 to 250 words. It should include the research question, the methods used, the key findings, and the implications of the results. The abstract should be written in a concise and clear manner to allow readers to quickly grasp the essence of the research.

Introduction

The introduction section of a research paper provides background information about the research problem, the research question, and the research objectives. It also outlines the significance of the research, the research gap that it aims to fill, and the approach taken to address the research question. Finally, the introduction section ends with a clear statement of the research hypothesis or research question.

Literature Review

The literature review section of a research paper provides an overview of the existing literature on the topic of study. It includes a critical analysis and synthesis of the literature, highlighting the key concepts, themes, and debates. The literature review should also demonstrate the research gap and how the current study seeks to address it.

The methods section of a research paper describes the research design, the sample selection, the data collection and analysis procedures, and the statistical methods used to analyze the data. This section should provide sufficient detail for other researchers to replicate the study.

The results section presents the findings of the research, using tables, graphs, and figures to illustrate the data. The findings should be presented in a clear and concise manner, with reference to the research question and hypothesis.

The discussion section of a research paper interprets the findings and discusses their implications for the research question, the literature review, and the field of study. It should also address the limitations of the study and suggest future research directions.

The conclusion section summarizes the main findings of the study, restates the research question and hypothesis, and provides a final reflection on the significance of the research.

The references section provides a list of all the sources cited in the paper, following a specific citation style such as APA, MLA or Chicago.

How to Write Research Paper

You can write Research Paper by the following guide:

  • Choose a Topic: The first step is to select a topic that interests you and is relevant to your field of study. Brainstorm ideas and narrow down to a research question that is specific and researchable.
  • Conduct a Literature Review: The literature review helps you identify the gap in the existing research and provides a basis for your research question. It also helps you to develop a theoretical framework and research hypothesis.
  • Develop a Thesis Statement : The thesis statement is the main argument of your research paper. It should be clear, concise and specific to your research question.
  • Plan your Research: Develop a research plan that outlines the methods, data sources, and data analysis procedures. This will help you to collect and analyze data effectively.
  • Collect and Analyze Data: Collect data using various methods such as surveys, interviews, observations, or experiments. Analyze data using statistical tools or other qualitative methods.
  • Organize your Paper : Organize your paper into sections such as Introduction, Literature Review, Methods, Results, Discussion, and Conclusion. Ensure that each section is coherent and follows a logical flow.
  • Write your Paper : Start by writing the introduction, followed by the literature review, methods, results, discussion, and conclusion. Ensure that your writing is clear, concise, and follows the required formatting and citation styles.
  • Edit and Proofread your Paper: Review your paper for grammar and spelling errors, and ensure that it is well-structured and easy to read. Ask someone else to review your paper to get feedback and suggestions for improvement.
  • Cite your Sources: Ensure that you properly cite all sources used in your research paper. This is essential for giving credit to the original authors and avoiding plagiarism.

Research Paper Example

Note : The below example research paper is for illustrative purposes only and is not an actual research paper. Actual research papers may have different structures, contents, and formats depending on the field of study, research question, data collection and analysis methods, and other factors. Students should always consult with their professors or supervisors for specific guidelines and expectations for their research papers.

Research Paper Example sample for Students:

Title: The Impact of Social Media on Mental Health among Young Adults

Abstract: This study aims to investigate the impact of social media use on the mental health of young adults. A literature review was conducted to examine the existing research on the topic. A survey was then administered to 200 university students to collect data on their social media use, mental health status, and perceived impact of social media on their mental health. The results showed that social media use is positively associated with depression, anxiety, and stress. The study also found that social comparison, cyberbullying, and FOMO (Fear of Missing Out) are significant predictors of mental health problems among young adults.

Introduction: Social media has become an integral part of modern life, particularly among young adults. While social media has many benefits, including increased communication and social connectivity, it has also been associated with negative outcomes, such as addiction, cyberbullying, and mental health problems. This study aims to investigate the impact of social media use on the mental health of young adults.

Literature Review: The literature review highlights the existing research on the impact of social media use on mental health. The review shows that social media use is associated with depression, anxiety, stress, and other mental health problems. The review also identifies the factors that contribute to the negative impact of social media, including social comparison, cyberbullying, and FOMO.

Methods : A survey was administered to 200 university students to collect data on their social media use, mental health status, and perceived impact of social media on their mental health. The survey included questions on social media use, mental health status (measured using the DASS-21), and perceived impact of social media on their mental health. Data were analyzed using descriptive statistics and regression analysis.

Results : The results showed that social media use is positively associated with depression, anxiety, and stress. The study also found that social comparison, cyberbullying, and FOMO are significant predictors of mental health problems among young adults.

Discussion : The study’s findings suggest that social media use has a negative impact on the mental health of young adults. The study highlights the need for interventions that address the factors contributing to the negative impact of social media, such as social comparison, cyberbullying, and FOMO.

Conclusion : In conclusion, social media use has a significant impact on the mental health of young adults. The study’s findings underscore the need for interventions that promote healthy social media use and address the negative outcomes associated with social media use. Future research can explore the effectiveness of interventions aimed at reducing the negative impact of social media on mental health. Additionally, longitudinal studies can investigate the long-term effects of social media use on mental health.

Limitations : The study has some limitations, including the use of self-report measures and a cross-sectional design. The use of self-report measures may result in biased responses, and a cross-sectional design limits the ability to establish causality.

Implications: The study’s findings have implications for mental health professionals, educators, and policymakers. Mental health professionals can use the findings to develop interventions that address the negative impact of social media use on mental health. Educators can incorporate social media literacy into their curriculum to promote healthy social media use among young adults. Policymakers can use the findings to develop policies that protect young adults from the negative outcomes associated with social media use.

References :

  • Twenge, J. M., & Campbell, W. K. (2019). Associations between screen time and lower psychological well-being among children and adolescents: Evidence from a population-based study. Preventive medicine reports, 15, 100918.
  • Primack, B. A., Shensa, A., Escobar-Viera, C. G., Barrett, E. L., Sidani, J. E., Colditz, J. B., … & James, A. E. (2017). Use of multiple social media platforms and symptoms of depression and anxiety: A nationally-representative study among US young adults. Computers in Human Behavior, 69, 1-9.
  • Van der Meer, T. G., & Verhoeven, J. W. (2017). Social media and its impact on academic performance of students. Journal of Information Technology Education: Research, 16, 383-398.

Appendix : The survey used in this study is provided below.

Social Media and Mental Health Survey

  • How often do you use social media per day?
  • Less than 30 minutes
  • 30 minutes to 1 hour
  • 1 to 2 hours
  • 2 to 4 hours
  • More than 4 hours
  • Which social media platforms do you use?
  • Others (Please specify)
  • How often do you experience the following on social media?
  • Social comparison (comparing yourself to others)
  • Cyberbullying
  • Fear of Missing Out (FOMO)
  • Have you ever experienced any of the following mental health problems in the past month?
  • Do you think social media use has a positive or negative impact on your mental health?
  • Very positive
  • Somewhat positive
  • Somewhat negative
  • Very negative
  • In your opinion, which factors contribute to the negative impact of social media on mental health?
  • Social comparison
  • In your opinion, what interventions could be effective in reducing the negative impact of social media on mental health?
  • Education on healthy social media use
  • Counseling for mental health problems caused by social media
  • Social media detox programs
  • Regulation of social media use

Thank you for your participation!

Applications of Research Paper

Research papers have several applications in various fields, including:

  • Advancing knowledge: Research papers contribute to the advancement of knowledge by generating new insights, theories, and findings that can inform future research and practice. They help to answer important questions, clarify existing knowledge, and identify areas that require further investigation.
  • Informing policy: Research papers can inform policy decisions by providing evidence-based recommendations for policymakers. They can help to identify gaps in current policies, evaluate the effectiveness of interventions, and inform the development of new policies and regulations.
  • Improving practice: Research papers can improve practice by providing evidence-based guidance for professionals in various fields, including medicine, education, business, and psychology. They can inform the development of best practices, guidelines, and standards of care that can improve outcomes for individuals and organizations.
  • Educating students : Research papers are often used as teaching tools in universities and colleges to educate students about research methods, data analysis, and academic writing. They help students to develop critical thinking skills, research skills, and communication skills that are essential for success in many careers.
  • Fostering collaboration: Research papers can foster collaboration among researchers, practitioners, and policymakers by providing a platform for sharing knowledge and ideas. They can facilitate interdisciplinary collaborations and partnerships that can lead to innovative solutions to complex problems.

When to Write Research Paper

Research papers are typically written when a person has completed a research project or when they have conducted a study and have obtained data or findings that they want to share with the academic or professional community. Research papers are usually written in academic settings, such as universities, but they can also be written in professional settings, such as research organizations, government agencies, or private companies.

Here are some common situations where a person might need to write a research paper:

  • For academic purposes: Students in universities and colleges are often required to write research papers as part of their coursework, particularly in the social sciences, natural sciences, and humanities. Writing research papers helps students to develop research skills, critical thinking skills, and academic writing skills.
  • For publication: Researchers often write research papers to publish their findings in academic journals or to present their work at academic conferences. Publishing research papers is an important way to disseminate research findings to the academic community and to establish oneself as an expert in a particular field.
  • To inform policy or practice : Researchers may write research papers to inform policy decisions or to improve practice in various fields. Research findings can be used to inform the development of policies, guidelines, and best practices that can improve outcomes for individuals and organizations.
  • To share new insights or ideas: Researchers may write research papers to share new insights or ideas with the academic or professional community. They may present new theories, propose new research methods, or challenge existing paradigms in their field.

Purpose of Research Paper

The purpose of a research paper is to present the results of a study or investigation in a clear, concise, and structured manner. Research papers are written to communicate new knowledge, ideas, or findings to a specific audience, such as researchers, scholars, practitioners, or policymakers. The primary purposes of a research paper are:

  • To contribute to the body of knowledge : Research papers aim to add new knowledge or insights to a particular field or discipline. They do this by reporting the results of empirical studies, reviewing and synthesizing existing literature, proposing new theories, or providing new perspectives on a topic.
  • To inform or persuade: Research papers are written to inform or persuade the reader about a particular issue, topic, or phenomenon. They present evidence and arguments to support their claims and seek to persuade the reader of the validity of their findings or recommendations.
  • To advance the field: Research papers seek to advance the field or discipline by identifying gaps in knowledge, proposing new research questions or approaches, or challenging existing assumptions or paradigms. They aim to contribute to ongoing debates and discussions within a field and to stimulate further research and inquiry.
  • To demonstrate research skills: Research papers demonstrate the author’s research skills, including their ability to design and conduct a study, collect and analyze data, and interpret and communicate findings. They also demonstrate the author’s ability to critically evaluate existing literature, synthesize information from multiple sources, and write in a clear and structured manner.

Characteristics of Research Paper

Research papers have several characteristics that distinguish them from other forms of academic or professional writing. Here are some common characteristics of research papers:

  • Evidence-based: Research papers are based on empirical evidence, which is collected through rigorous research methods such as experiments, surveys, observations, or interviews. They rely on objective data and facts to support their claims and conclusions.
  • Structured and organized: Research papers have a clear and logical structure, with sections such as introduction, literature review, methods, results, discussion, and conclusion. They are organized in a way that helps the reader to follow the argument and understand the findings.
  • Formal and objective: Research papers are written in a formal and objective tone, with an emphasis on clarity, precision, and accuracy. They avoid subjective language or personal opinions and instead rely on objective data and analysis to support their arguments.
  • Citations and references: Research papers include citations and references to acknowledge the sources of information and ideas used in the paper. They use a specific citation style, such as APA, MLA, or Chicago, to ensure consistency and accuracy.
  • Peer-reviewed: Research papers are often peer-reviewed, which means they are evaluated by other experts in the field before they are published. Peer-review ensures that the research is of high quality, meets ethical standards, and contributes to the advancement of knowledge in the field.
  • Objective and unbiased: Research papers strive to be objective and unbiased in their presentation of the findings. They avoid personal biases or preconceptions and instead rely on the data and analysis to draw conclusions.

Advantages of Research Paper

Research papers have many advantages, both for the individual researcher and for the broader academic and professional community. Here are some advantages of research papers:

  • Contribution to knowledge: Research papers contribute to the body of knowledge in a particular field or discipline. They add new information, insights, and perspectives to existing literature and help advance the understanding of a particular phenomenon or issue.
  • Opportunity for intellectual growth: Research papers provide an opportunity for intellectual growth for the researcher. They require critical thinking, problem-solving, and creativity, which can help develop the researcher’s skills and knowledge.
  • Career advancement: Research papers can help advance the researcher’s career by demonstrating their expertise and contributions to the field. They can also lead to new research opportunities, collaborations, and funding.
  • Academic recognition: Research papers can lead to academic recognition in the form of awards, grants, or invitations to speak at conferences or events. They can also contribute to the researcher’s reputation and standing in the field.
  • Impact on policy and practice: Research papers can have a significant impact on policy and practice. They can inform policy decisions, guide practice, and lead to changes in laws, regulations, or procedures.
  • Advancement of society: Research papers can contribute to the advancement of society by addressing important issues, identifying solutions to problems, and promoting social justice and equality.

Limitations of Research Paper

Research papers also have some limitations that should be considered when interpreting their findings or implications. Here are some common limitations of research papers:

  • Limited generalizability: Research findings may not be generalizable to other populations, settings, or contexts. Studies often use specific samples or conditions that may not reflect the broader population or real-world situations.
  • Potential for bias : Research papers may be biased due to factors such as sample selection, measurement errors, or researcher biases. It is important to evaluate the quality of the research design and methods used to ensure that the findings are valid and reliable.
  • Ethical concerns: Research papers may raise ethical concerns, such as the use of vulnerable populations or invasive procedures. Researchers must adhere to ethical guidelines and obtain informed consent from participants to ensure that the research is conducted in a responsible and respectful manner.
  • Limitations of methodology: Research papers may be limited by the methodology used to collect and analyze data. For example, certain research methods may not capture the complexity or nuance of a particular phenomenon, or may not be appropriate for certain research questions.
  • Publication bias: Research papers may be subject to publication bias, where positive or significant findings are more likely to be published than negative or non-significant findings. This can skew the overall findings of a particular area of research.
  • Time and resource constraints: Research papers may be limited by time and resource constraints, which can affect the quality and scope of the research. Researchers may not have access to certain data or resources, or may be unable to conduct long-term studies due to practical limitations.

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13.1 Formatting a Research Paper

Learning objectives.

  • Identify the major components of a research paper written using American Psychological Association (APA) style.
  • Apply general APA style and formatting conventions in a research paper.

In this chapter, you will learn how to use APA style , the documentation and formatting style followed by the American Psychological Association, as well as MLA style , from the Modern Language Association. There are a few major formatting styles used in academic texts, including AMA, Chicago, and Turabian:

  • AMA (American Medical Association) for medicine, health, and biological sciences
  • APA (American Psychological Association) for education, psychology, and the social sciences
  • Chicago—a common style used in everyday publications like magazines, newspapers, and books
  • MLA (Modern Language Association) for English, literature, arts, and humanities
  • Turabian—another common style designed for its universal application across all subjects and disciplines

While all the formatting and citation styles have their own use and applications, in this chapter we focus our attention on the two styles you are most likely to use in your academic studies: APA and MLA.

If you find that the rules of proper source documentation are difficult to keep straight, you are not alone. Writing a good research paper is, in and of itself, a major intellectual challenge. Having to follow detailed citation and formatting guidelines as well may seem like just one more task to add to an already-too-long list of requirements.

Following these guidelines, however, serves several important purposes. First, it signals to your readers that your paper should be taken seriously as a student’s contribution to a given academic or professional field; it is the literary equivalent of wearing a tailored suit to a job interview. Second, it shows that you respect other people’s work enough to give them proper credit for it. Finally, it helps your reader find additional materials if he or she wishes to learn more about your topic.

Furthermore, producing a letter-perfect APA-style paper need not be burdensome. Yes, it requires careful attention to detail. However, you can simplify the process if you keep these broad guidelines in mind:

  • Work ahead whenever you can. Chapter 11 “Writing from Research: What Will I Learn?” includes tips for keeping track of your sources early in the research process, which will save time later on.
  • Get it right the first time. Apply APA guidelines as you write, so you will not have much to correct during the editing stage. Again, putting in a little extra time early on can save time later.
  • Use the resources available to you. In addition to the guidelines provided in this chapter, you may wish to consult the APA website at http://www.apa.org or the Purdue University Online Writing lab at http://owl.english.purdue.edu , which regularly updates its online style guidelines.

General Formatting Guidelines

This chapter provides detailed guidelines for using the citation and formatting conventions developed by the American Psychological Association, or APA. Writers in disciplines as diverse as astrophysics, biology, psychology, and education follow APA style. The major components of a paper written in APA style are listed in the following box.

These are the major components of an APA-style paper:

Body, which includes the following:

  • Headings and, if necessary, subheadings to organize the content
  • In-text citations of research sources
  • References page

All these components must be saved in one document, not as separate documents.

The title page of your paper includes the following information:

  • Title of the paper
  • Author’s name
  • Name of the institution with which the author is affiliated
  • Header at the top of the page with the paper title (in capital letters) and the page number (If the title is lengthy, you may use a shortened form of it in the header.)

List the first three elements in the order given in the previous list, centered about one third of the way down from the top of the page. Use the headers and footers tool of your word-processing program to add the header, with the title text at the left and the page number in the upper-right corner. Your title page should look like the following example.

Beyond the Hype: Evaluating Low-Carb Diets cover page

The next page of your paper provides an abstract , or brief summary of your findings. An abstract does not need to be provided in every paper, but an abstract should be used in papers that include a hypothesis. A good abstract is concise—about one hundred fifty to two hundred fifty words—and is written in an objective, impersonal style. Your writing voice will not be as apparent here as in the body of your paper. When writing the abstract, take a just-the-facts approach, and summarize your research question and your findings in a few sentences.

In Chapter 12 “Writing a Research Paper” , you read a paper written by a student named Jorge, who researched the effectiveness of low-carbohydrate diets. Read Jorge’s abstract. Note how it sums up the major ideas in his paper without going into excessive detail.

Beyond the Hype: Abstract

Write an abstract summarizing your paper. Briefly introduce the topic, state your findings, and sum up what conclusions you can draw from your research. Use the word count feature of your word-processing program to make sure your abstract does not exceed one hundred fifty words.

Depending on your field of study, you may sometimes write research papers that present extensive primary research, such as your own experiment or survey. In your abstract, summarize your research question and your findings, and briefly indicate how your study relates to prior research in the field.

Margins, Pagination, and Headings

APA style requirements also address specific formatting concerns, such as margins, pagination, and heading styles, within the body of the paper. Review the following APA guidelines.

Use these general guidelines to format the paper:

  • Set the top, bottom, and side margins of your paper at 1 inch.
  • Use double-spaced text throughout your paper.
  • Use a standard font, such as Times New Roman or Arial, in a legible size (10- to 12-point).
  • Use continuous pagination throughout the paper, including the title page and the references section. Page numbers appear flush right within your header.
  • Section headings and subsection headings within the body of your paper use different types of formatting depending on the level of information you are presenting. Additional details from Jorge’s paper are provided.

Cover Page

Begin formatting the final draft of your paper according to APA guidelines. You may work with an existing document or set up a new document if you choose. Include the following:

  • Your title page
  • The abstract you created in Note 13.8 “Exercise 1”
  • Correct headers and page numbers for your title page and abstract

APA style uses section headings to organize information, making it easy for the reader to follow the writer’s train of thought and to know immediately what major topics are covered. Depending on the length and complexity of the paper, its major sections may also be divided into subsections, sub-subsections, and so on. These smaller sections, in turn, use different heading styles to indicate different levels of information. In essence, you are using headings to create a hierarchy of information.

The following heading styles used in APA formatting are listed in order of greatest to least importance:

  • Section headings use centered, boldface type. Headings use title case, with important words in the heading capitalized.
  • Subsection headings use left-aligned, boldface type. Headings use title case.
  • The third level uses left-aligned, indented, boldface type. Headings use a capital letter only for the first word, and they end in a period.
  • The fourth level follows the same style used for the previous level, but the headings are boldfaced and italicized.
  • The fifth level follows the same style used for the previous level, but the headings are italicized and not boldfaced.

Visually, the hierarchy of information is organized as indicated in Table 13.1 “Section Headings” .

Table 13.1 Section Headings

Level of Information Text Example
Level 1
Level 2
Level 3     
Level 4         
Level 5             

A college research paper may not use all the heading levels shown in Table 13.1 “Section Headings” , but you are likely to encounter them in academic journal articles that use APA style. For a brief paper, you may find that level 1 headings suffice. Longer or more complex papers may need level 2 headings or other lower-level headings to organize information clearly. Use your outline to craft your major section headings and determine whether any subtopics are substantial enough to require additional levels of headings.

Working with the document you developed in Note 13.11 “Exercise 2” , begin setting up the heading structure of the final draft of your research paper according to APA guidelines. Include your title and at least two to three major section headings, and follow the formatting guidelines provided above. If your major sections should be broken into subsections, add those headings as well. Use your outline to help you.

Because Jorge used only level 1 headings, his Exercise 3 would look like the following:

Level of Information Text Example
Level 1
Level 1
Level 1
Level 1

Citation Guidelines

In-text citations.

Throughout the body of your paper, include a citation whenever you quote or paraphrase material from your research sources. As you learned in Chapter 11 “Writing from Research: What Will I Learn?” , the purpose of citations is twofold: to give credit to others for their ideas and to allow your reader to follow up and learn more about the topic if desired. Your in-text citations provide basic information about your source; each source you cite will have a longer entry in the references section that provides more detailed information.

In-text citations must provide the name of the author or authors and the year the source was published. (When a given source does not list an individual author, you may provide the source title or the name of the organization that published the material instead.) When directly quoting a source, it is also required that you include the page number where the quote appears in your citation.

This information may be included within the sentence or in a parenthetical reference at the end of the sentence, as in these examples.

Epstein (2010) points out that “junk food cannot be considered addictive in the same way that we think of psychoactive drugs as addictive” (p. 137).

Here, the writer names the source author when introducing the quote and provides the publication date in parentheses after the author’s name. The page number appears in parentheses after the closing quotation marks and before the period that ends the sentence.

Addiction researchers caution that “junk food cannot be considered addictive in the same way that we think of psychoactive drugs as addictive” (Epstein, 2010, p. 137).

Here, the writer provides a parenthetical citation at the end of the sentence that includes the author’s name, the year of publication, and the page number separated by commas. Again, the parenthetical citation is placed after the closing quotation marks and before the period at the end of the sentence.

As noted in the book Junk Food, Junk Science (Epstein, 2010, p. 137), “junk food cannot be considered addictive in the same way that we think of psychoactive drugs as addictive.”

Here, the writer chose to mention the source title in the sentence (an optional piece of information to include) and followed the title with a parenthetical citation. Note that the parenthetical citation is placed before the comma that signals the end of the introductory phrase.

David Epstein’s book Junk Food, Junk Science (2010) pointed out that “junk food cannot be considered addictive in the same way that we think of psychoactive drugs as addictive” (p. 137).

Another variation is to introduce the author and the source title in your sentence and include the publication date and page number in parentheses within the sentence or at the end of the sentence. As long as you have included the essential information, you can choose the option that works best for that particular sentence and source.

Citing a book with a single author is usually a straightforward task. Of course, your research may require that you cite many other types of sources, such as books or articles with more than one author or sources with no individual author listed. You may also need to cite sources available in both print and online and nonprint sources, such as websites and personal interviews. Chapter 13 “APA and MLA Documentation and Formatting” , Section 13.2 “Citing and Referencing Techniques” and Section 13.3 “Creating a References Section” provide extensive guidelines for citing a variety of source types.

Writing at Work

APA is just one of several different styles with its own guidelines for documentation, formatting, and language usage. Depending on your field of interest, you may be exposed to additional styles, such as the following:

  • MLA style. Determined by the Modern Languages Association and used for papers in literature, languages, and other disciplines in the humanities.
  • Chicago style. Outlined in the Chicago Manual of Style and sometimes used for papers in the humanities and the sciences; many professional organizations use this style for publications as well.
  • Associated Press (AP) style. Used by professional journalists.

References List

The brief citations included in the body of your paper correspond to the more detailed citations provided at the end of the paper in the references section. In-text citations provide basic information—the author’s name, the publication date, and the page number if necessary—while the references section provides more extensive bibliographical information. Again, this information allows your reader to follow up on the sources you cited and do additional reading about the topic if desired.

The specific format of entries in the list of references varies slightly for different source types, but the entries generally include the following information:

  • The name(s) of the author(s) or institution that wrote the source
  • The year of publication and, where applicable, the exact date of publication
  • The full title of the source
  • For books, the city of publication
  • For articles or essays, the name of the periodical or book in which the article or essay appears
  • For magazine and journal articles, the volume number, issue number, and pages where the article appears
  • For sources on the web, the URL where the source is located

The references page is double spaced and lists entries in alphabetical order by the author’s last name. If an entry continues for more than one line, the second line and each subsequent line are indented five spaces. Review the following example. ( Chapter 13 “APA and MLA Documentation and Formatting” , Section 13.3 “Creating a References Section” provides extensive guidelines for formatting reference entries for different types of sources.)

References Section

In APA style, book and article titles are formatted in sentence case, not title case. Sentence case means that only the first word is capitalized, along with any proper nouns.

Key Takeaways

  • Following proper citation and formatting guidelines helps writers ensure that their work will be taken seriously, give proper credit to other authors for their work, and provide valuable information to readers.
  • Working ahead and taking care to cite sources correctly the first time are ways writers can save time during the editing stage of writing a research paper.
  • APA papers usually include an abstract that concisely summarizes the paper.
  • APA papers use a specific headings structure to provide a clear hierarchy of information.
  • In APA papers, in-text citations usually include the name(s) of the author(s) and the year of publication.
  • In-text citations correspond to entries in the references section, which provide detailed bibliographical information about a source.

Writing for Success Copyright © 2015 by University of Minnesota is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License , except where otherwise noted.

How to Write a Research Paper

Academic Writing Service

If you already have a headache trying to understand what research paper is all about, we have created an ultimate guide for you on how to write a research paper. You will find all the answers to your questions regarding structure, planning, doing investigation, finding the topic that appeals to you. Plus, you will find out the secret to an excellent paper. Are you at the edge of your seat? Let us start with the basics then.

  • What is a Research Paper
  • Reasons for Writing a Research Paper
  • Report Papers and Thesis Papers
  • How to Start a Research Paper
  • How to Choose a Topic for a Research Paper
  • How to Write a Proposal for a Research Paper
  • How to Write a Research Plan
  • How to Do Research
  • How to Write an Outline for a Research Paper
  • How to Write a Thesis Statement for a Research Paper
  • How to Write a Research Paper Rough Draft
  • How to Write an Introduction for a Research Paper
  • How to Write a Body of a Research Paper
  • How to Write a Conclusion for a Research Paper
  • How to Write an Abstract for a Research Paper
  • How to Revise and Edit a Research Paper
  • How to Write a Bibliography for a Research Paper
  • What Makes a Good Research Paper

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What is a research paper.

How to Write a Research Paper

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You probably know the saying ‘the devil is not as black as he is painted’. This particular saying is absolutely true when it comes to writing a research paper. Your feet are cold even with the thought of this assignment. You have heard terrifying stories from older students. You have never done this before, so certainly you are scared. What is a research paper? How should I start? What are all these requirements about?

Luckily, you have a friend in need. That is our writing service. First and foremost, let us clarify the definition. A research paper is a piece of academic writing that provides information about a particular topic that you’ve researched . In other words, you choose a topic: about historical events, the work of some artist, some social issues etc. Then you collect data on the given topic and analyze it. Finally, you put your analysis on paper. See, it is not as scary as it seems. If you are still having doubts, whether you can handle it yourself, we are here to help you. Our team of writers can help you choose the topic, or give you advice on how to plan your work, or how to start, or craft a paper for you. Just contact us 24/7 and see everything yourself.

5 Reasons for Writing a Research Paper

Why should I spend my time writing some academic paper? What is the use of it? Is not some practical knowledge more important? The list of questions is endless when it comes to a research paper. That is why we have outlined 5 main reasons why writing a research paper is a good thing.

  • You will learn how to organize your time

If you want to write a research paper, you will have to learn how to manage your time. This type of assignment cannot be done overnight. It requires careful planning and you will need to learn how to do it. Later, you will be able to use these time-managing skills in your personal life, so why not developing them?

  • You will discover your writing skills

You cannot know something before you try it. This rule relates to writing as well. You cannot claim that you cannot write until you try it yourself. It will be really difficult at the beginning, but then the words will come to your head themselves.

  • You will improve your analytical skills

Writing a research paper is all about investigation and analysis. You will need to collect data, examine and classify it. These skills are needed in modern life more than anything else is.

  • You will gain confidence

Once you do your own research, it gives you the feeling of confidence in yourself. The reason is simple human brain likes solving puzzles and your assignment is just another puzzle to be solved.

  • You will learn how to persuade the reader

When you write your paper, you should always remember that you are writing it for someone to read. Moreover, you want this someone to believe in your ideas. For this reason, you will have to learn different convincing methods and techniques. You will learn how to make your writing persuasive. In turns, you will be able to use these methods in real life.

What is the Difference between Report and Thesis Papers?

A common question is ‘what is the difference between a report paper and a thesis paper?’ The difference lies in the aim of these two assignments. While the former aims at presenting the information, the latter aims at providing your opinion on the matter. In other words, in a report paper you have to summarize your findings. In a thesis paper, you choose some issue and defend your point of view by persuading the reader. It is that simple.

A thesis paper is a more common assignment than a report paper. This task will help a professor to evaluate your analytical skills and skills to present your ideas logically. These skills are more important than just the ability to collect and summarize data.

How to Write a Research Paper Step by Step

Research comes from the French word  rechercher , meaning “to seek out.” Writing a research paper requires you to seek out information about a subject, take a stand on it, and back it up with the opinions, ideas, and views of others. What results is a printed paper variously known as a term paper or library paper, usually between five and fifteen pages long—most instructors specify a minimum length—in which you present your views and findings on the chosen subject.

How to Write a Research Paper

It is not a secret that the majority of students hate writing a research paper. The reason is simple it steals your time and energy. Not to mention, constant anxiety that you will not be able to meet the deadline or that you will forget about some academic requirement.

We will not lie to you; a research paper is a difficult assignment. You will have to spend a lot of time. You will need to read, to analyze, and to search for the material. You will probably be stuck sometimes. However, if you organize your work smart, you will gain something that is worth all the effort – knowledge, experience, and high grades.

The reason why many students fail writing a research paper is that nobody explained them how to start and how to plan their work. Luckily, you have found our writing service and we are ready to shed the light on this dark matter.

We have created a step by step guide for you on how to write a research paper. We will dwell upon the structure, the writing tips, the writing strategies as well as academic requirements. Read this whole article and you will see that you can handle writing this assignment and our team of writers is here to assist you.

How to Start a Research Paper?

How to Start a Research Paper

It all starts with the assignment. Your professor gives you the task. It may be either some general issue or specific topic to write about. Your assignment is your first guide to success. If you understand what you need to do according to the assignment, you are on the road to high results. Do not be scared to clarify your task if you need to. There is nothing wrong in asking a question if you want to do something right. You can ask your professor or you can ask our writers who know a thing or two in academic writing.

It is essential to understand the assignment. A good beginning makes a good ending, so start smart.

Learn how to start a research paper .

Choosing a Topic for a Research Paper

How to Choose a Topic for a Research Paper

We have already mentioned that it is not enough to do great research. You need to persuade the reader that you have made some great research. What convinces better that an eye-catching topic? That is why it is important to understand how to choose a topic for a research paper.

First, you need to delimit the general idea to a more specific one. Secondly, you need to find what makes this topic interesting for you and for the academia. Finally, you need to refine you topic. Remember, it is not something you will do in one day. You can be reshaping your topic throughout your whole writing process. Still, reshaping not changing it completely. That is why keep in your head one main idea: your topic should be precise and compelling .

Learn how to choose a topic for a research paper .

How to Write a Proposal for a Research Paper?

How to Write a Proposal for a Research Paper

If you do not know what a proposal is, let us explain it to you. A proposal should answer three main questions:

  • What is the main aim of your investigation?
  • Why is your investigation important?
  • How are you going to achieve the results?

In other words, proposal should show why your topic is interesting and how you are going to prove it. As to writing requirements, they may differ. That is why make sure you find out all the details at your department. You can ask your departmental administrator or find information online at department’s site. It is crucial to follow all the administrative requirements, as it will influence your grade.

Learn how to write a proposal for a research paper .

How to Write a Research Plan?

How to Write a Research Plan

The next step is writing a plan. You have already decided on the main issues, you have chosen the bibliography, and you have clarified the methods. Here comes the planning. If you want to avoid writer’s block, you have to structure you work. Discuss your strategies and ideas with your instructor. Think thoroughly why you need to present some data and ideas first and others second. Remember that there are basic structure elements that your research paper should include:

  • Thesis Statement
  • Introduction
  • Bibliography

You should keep in mind this skeleton when planning your work. This will keep your mind sharp and your ideas will flow logically.

Learn how to write a research plan .

How to Do Research?

How to Do Research

Your research will include three stages: collecting data, reading and analyzing it, and writing itself.

First, you need to collect all the material that you will need for you investigation: films, documents, surveys, interviews, and others. Secondly, you will have to read and analyze. This step is tricky, as you need to do this part smart. It is not enough just to read, as you cannot keep in mind all the information. It is essential that you make notes and write down your ideas while analyzing some data. When you get down to the stage number three, writing itself, you will already have the main ideas written on your notes. Plus, remember to jot down the reference details. You will then appreciate this trick when you will have to write the bibliography.

If you do your research this way, it will be much easier for you to write the paper. You will already have blocks of your ideas written down and you will just need to add some material and refine your paper.

Learn how to do research .

How to Write an Outline for a Research Paper?

How to Write an Outline for a Research Paper

To make your paper well organized you need to write an outline. Your outline will serve as your guiding star through the writing process. With a great outline you will not get sidetracked, because you will have a structured plan to follow. Both you and the reader will benefit from your outline. You present your ideas logically and you make your writing coherent according to your plan. As a result, this outline guides the reader through your paper and the reader enjoys the way you demonstrate your ideas.

Learn how to write an outline for a research paper . See research paper outline examples .

How to Write a Thesis Statement for a Research Paper?

How to Write a Thesis Statement for a Research Paper

Briefly, the thesis is the main argument of your research paper. It should be precise, convincing and logical. Your thesis statement should include your point of view supported by evidence or logic. Still, remember it should be precise. You should not beat around the bush, or provide all the possible evidence you have found. It is usually a single sentence that shows your argument. In on sentence you should make a claim, explain why it significant and convince the reader that your point of view is important.

Learn how to write a thesis statement for a research paper . See research paper thesis statement examples .

Should I Write a Rough Draft for a Research Paper?

How to Write a Research Paper Rough Draft

Do you know any writer who put their ideas on paper, then never edited them and just published? Probably, no writer did so. Writing a research paper is no exception. It is impossible to cope with this assignment without writing a rough draft.

Your draft will help you understand what you need to polish to make your paper perfect. All the requirements, academic standards make it difficult to do everything flawlessly at the first attempt. Make sure you know all the formatting requirements: margins, words quantity, reference requirements, formatting styles etc.

Learn how to write a rough draft for a research paper .

How to Write an Introduction for a Research Paper?

How to Write an Introduction for a Research Paper

Let us make it more vivid for you. We have narrowed down the tips on writing an introduction to the three main ones:

  • Include your thesis in your introduction

Remember to include the thesis statement in your introduction. Usually, it goes at the end of the first paragraph.

  • Present the main ideas of the body

You should tell the main topics you are going to discuss in the main body. For this reason, before writing this part of introduction, make sure you know what is your main body is going to be about. It should include your main ideas.

  • Polish your thesis and introduction

When you finish the main body of your paper, come back to the thesis statement and introduction. Restate something if needed. Just make it perfect; because introduction is like the trailer to your paper, it should make the reader want to read the whole piece.

Learn how to write an introduction for a research paper . See research paper introduction examples .

How to Write a Body of a Research Paper?

How to Write a Body of a Research Paper

A body is the main part of your research paper. In this part, you will include all the needed evidence; you will provide the examples and support your argument.

It is important to structure your paragraphs thoroughly. That is to say, topic sentence and the evidence supporting the topic. Stay focused and do not be sidetracked. You have your outline, so follow it.

Here are the main tips to keep in head when writing a body of a research paper:

  • Let the ideas flow logically
  • Include only relevant information
  • Provide the evidence
  • Structure the paragraphs
  • Make the coherent transition from one paragraph to another

See? When it is all structured, it is not as scary as it seemed at the beginning. Still, if you have doubts, you can always ask our writers for help.

Learn how to write a body of a research paper . See research paper transition examples .

How to Write a Conclusion for a Research Paper?

How to Write a Conclusion for a Research Paper

Writing a good conclusion is important as writing any other part of the paper. Remember that conclusion is not a summary of what you have mentioned before. A good conclusion should include your last strong statement.

If you have written everything according to the plan, the reader already knows why your investigation is important. The reader has already seen the evidence. The only thing left is a strong concluding thought that will organize all your findings.

Never include any new information in conclusion. You need to conclude, not to start a new discussion.

Learn how to write a conclusion for a research paper .

How to Write an Abstract for a Research Paper?

How to Write an Abstract for a Research Paper

An abstract is a brief summary of your paper, usually 100-200 words. You should provide the main gist of your paper in this short summary. An abstract can be informative, descriptive or proposal. Depending on the type of abstract, you need to write, the requirements will differ.

To write an informative abstract you have to provide the summary of the whole paper. Informative summary. In other words, you need to tell about the main points of your work, the methods used, the results and the conclusion of your research.

To write a descriptive abstract you will not have to provide any summery. You should write a short teaser of your paper. That is to say, you need to write an overview of your paper. The aim of a descriptive abstract is to interest the reader.

Finally, to write a proposal abstract you will need to write the basic summary as for the informative abstract. However, the difference is the following: you aim at persuading someone to let you write on the topic. That is why, a proposal abstract should present your topic as the one worth investigating.

Learn how to write an abstract for a research paper .

Should I Revise and Edit a Research Paper?

How to Revise and Edit a Research Paper

Revising and editing your paper is essential if you want to get high grades. Let us help you revise your paper smart:

  • Check your paper for spelling and grammar mistakes
  • Sharpen the vocabulary
  • Make sure there are no slang words in your paper
  • Examine your paper in terms of structure
  • Compare your topic, thesis statement to the whole piece
  • Check your paper for plagiarism

If you need assistance with proofreading and editing your paper, you can turn to the professional editors at our service. They will help you polish your paper to perfection.

Learn how to revise and edit a research paper .

How to Write a Bibliography for a Research Paper?

How to Write a Bibliography for a Research Paper

First, let us make it clear that bibliography and works cited are two different things. Works cited are those that you cited in your paper. Bibliography should include all the materials you used to do your research. Still, remember that bibliography requirements differ depending on the formatting style of your paper. For this reason, make sure you ask you professor all the requirements you need to meet to avoid any misunderstanding.

Learn how to write a bibliography for a research paper .

The Key Secret to a Good Research Paper

Now when you know all the stages of writing a research paper, you are ready to find the key to a good research paper:

  • Choose the topic that really interests you
  • Make the topic interesting for you even if it is not at the beginning
  • Follow the step by step guide and do not get sidetracked
  • Be persistent and believe in yourself
  • Really do research and write your paper from scratch
  • Learn the convincing writing techniques and use them
  • Follow the requirements of your assignment
  • Ask for help if needed from real professionals

Feeling more confident about your paper now? We are sure you do. Still, if you need help, you can always rely on us 24/7.

We hope we have made writing a research paper much easier for you. We realize that it requires lots of time and energy. We believe when you say that you cannot handle it anymore. For this reason, we have been helping students like you for years. Our professional team of writers is ready to tackle any challenge.

All our authors are experienced writers crafting excellent academic papers. We help students meet the deadline and get the top grades they want. You can see everything yourself. All you need to do is to place your order online and we will contact you. Writing a research paper with us is truly easy, so why do not you check it yourself?

Additional Resources for Research Paper Writing:

  • Anthropology Research
  • Career Research
  • Communication Research
  • Criminal Justice Research
  • Health Research
  • Political Science Research
  • Psychology Research
  • Sociology Research

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Chapter 12 Writing a Research Paper

12.1 creating a rough draft for a research paper, learning objectives.

  • Apply strategies for drafting an effective introduction and conclusion.
  • Identify when and how to summarize, paraphrase, and directly quote information from research sources.
  • Apply guidelines for citing sources within the body of the paper and the bibliography.
  • Use primary and secondary research to support ideas.
  • Identify the purposes for which writers use each type of research.

At last, you are ready to begin writing the rough draft of your research paper. Putting your thinking and research into words is exciting. It can also be challenging. In this section, you will learn strategies for handling the more challenging aspects of writing a research paper, such as integrating material from your sources, citing information correctly, and avoiding any misuse of your sources.

The Structure of a Research Paper

Research papers generally follow the same basic structure: an introduction that presents the writer’s thesis, a body section that develops the thesis with supporting points and evidence, and a conclusion that revisits the thesis and provides additional insights or suggestions for further research.

Your writing voice will come across most strongly in your introduction and conclusion, as you work to attract your readers’ interest and establish your thesis. These sections usually do not cite sources at length. They focus on the big picture, not specific details. In contrast, the body of your paper will cite sources extensively. As you present your ideas, you will support your points with details from your research.

Writing Your Introduction

There are several approaches to writing an introduction, each of which fulfills the same goals. The introduction should get readers’ attention, provide background information, and present the writer’s thesis. Many writers like to begin with one of the following catchy openers:

  • A surprising fact
  • A thought-provoking question
  • An attention-getting quote
  • A brief anecdote that illustrates a larger concept
  • A connection between your topic and your readers’ experiences

The next few sentences place the opening in context by presenting background information. From there, the writer builds toward a thesis, which is traditionally placed at the end of the introduction. Think of your thesis as a signpost that lets readers know in what direction the paper is headed.

Jorge decided to begin his research paper by connecting his topic to readers’ daily experiences. Read the first draft of his introduction. The thesis is underlined. Note how Jorge progresses from the opening sentences to background information to his thesis.

Beyond the Hype: Evaluating Low-Carb Diets

I. Introduction

Over the past decade, increasing numbers of Americans have jumped on the low-carb bandwagon. Some studies estimate that approximately 40 million Americans, or about 20 percent of the population, are attempting to restrict their intake of food high in carbohydrates (Sanders and Katz, 2004; Hirsch, 2004). Proponents of low-carb diets say they are not only the most effective way to lose weight, but they also yield health benefits such as lower blood pressure and improved cholesterol levels. Meanwhile, some doctors claim that low-carb diets are overrated and caution that their long-term effects are unknown. Although following a low-carbohydrate diet can benefit some people, these diets are not necessarily the best option for everyone who wants to lose weight or improve their health.

Write the introductory paragraph of your research paper. Try using one of the techniques listed in this section to write an engaging introduction. Be sure to include background information about the topic that leads to your thesis.

Writers often work out of sequence when writing a research paper. If you find yourself struggling to write an engaging introduction, you may wish to write the body of your paper first. Writing the body sections first will help you clarify your main points. Writing the introduction should then be easier. You may have a better sense of how to introduce the paper after you have drafted some or all of the body.

Writing Your Conclusion

In your introduction, you tell readers where they are headed. In your conclusion, you recap where they have been. For this reason, some writers prefer to write their conclusions soon after they have written their introduction. However, this method may not work for all writers. Other writers prefer to write their conclusion at the end of the paper, after writing the body paragraphs. No process is absolutely right or absolutely wrong; find the one that best suits you.

No matter when you compose the conclusion, it should sum up your main ideas and revisit your thesis. The conclusion should not simply echo the introduction or rely on bland summary statements, such as “In this paper, I have demonstrated that.…” In fact, avoid repeating your thesis verbatim from the introduction. Restate it in different words that reflect the new perspective gained through your research. That helps keep your ideas fresh for your readers. An effective writer might conclude a paper by asking a new question the research inspired, revisiting an anecdote presented earlier, or reminding readers of how the topic relates to their lives.

Writing at Work

If your job involves writing or reading scientific papers, it helps to understand how professional researchers use the structure described in this section. A scientific paper begins with an abstract that briefly summarizes the entire paper. The introduction explains the purpose of the research, briefly summarizes previous research, and presents the researchers’ hypothesis. The body provides details about the study, such as who participated in it, what the researchers measured, and what results they recorded. The conclusion presents the researchers’ interpretation of the data, or what they learned.

Using Source Material in Your Paper

One of the challenges of writing a research paper is successfully integrating your ideas with material from your sources. Your paper must explain what you think, or it will read like a disconnected string of facts and quotations. However, you also need to support your ideas with research, or they will seem insubstantial. How do you strike the right balance?

You have already taken a step in the right direction by writing your introduction. The introduction and conclusion function like the frame around a picture. They define and limit your topic and place your research in context.

In the body paragraphs of your paper, you will need to integrate ideas carefully at the paragraph level and at the sentence level. You will use topic sentences in your paragraphs to make sure readers understand the significance of any facts, details, or quotations you cite. You will also include sentences that transition between ideas from your research, either within a paragraph or between paragraphs. At the sentence level, you will need to think carefully about how you introduce paraphrased and quoted material.

Earlier you learned about summarizing, paraphrasing, and quoting when taking notes. In the next few sections, you will learn how to use these techniques in the body of your paper to weave in source material to support your ideas.

Summarizing Sources

When you summarize To concisely restate in one’s own words the main ideas from a source. material from a source, you zero in on the main points and restate them concisely in your own words. This technique is appropriate when only the major ideas are relevant to your paper or when you need to simplify complex information into a few key points for your readers.

Be sure to review the source material as you summarize it. Identify the main idea and restate it as concisely as you can—preferably in one sentence. Depending on your purpose, you may also add another sentence or two condensing any important details or examples. Check your summary to make sure it is accurate and complete.

In his draft, Jorge summarized research materials that presented scientists’ findings about low-carbohydrate diets. Read the following passage from a trade magazine article and Jorge’s summary of the article.

Assessing the Efficacy of Low-Carbohydrate Diets

Adrienne Howell, Ph.D.

Over the past few years, a number of clinical studies have explored whether high-protein, low-carbohydrate diets are more effective for weight loss than other frequently recommended diet plans, such as diets that drastically curtail fat intake (Pritikin) or that emphasize consuming lean meats, grains, vegetables, and a moderate amount of unsaturated fats (the Mediterranean diet). A 2009 study found that obese teenagers who followed a low-carbohydrate diet lost an average of 15.6 kilograms over a six-month period, whereas teenagers following a low-fat diet or a Mediterranean diet lost an average of 11.1 kilograms and 9.3 kilograms respectively. Two 2010 studies that measured weight loss for obese adults following these same three diet plans found similar results. Over three months, subjects on the low-carbohydrate diet plan lost anywhere from four to six kilograms more than subjects who followed other diet plans.

In three recent studies, researchers compared outcomes for obese subjects who followed either a low-carbohydrate diet, a low-fat diet, or a Mediterranean diet and found that subjects following a low-carbohydrate diet lost more weight in the same time (Howell, 2010).

A summary restates ideas in your own words—but for specialized or clinical terms, you may need to use terms that appear in the original source. For instance, Jorge used the term obese in his summary because related words such as heavy or overweight have a different clinical meaning.

On a separate sheet of paper, practice summarizing by writing a one-sentence summary of the same passage that Jorge already summarized.

Paraphrasing Sources

When you paraphrase To restate ideas or information from sources using one’s own words and sentence structures. material from a source, restate the information from an entire sentence or passage in your own words, using your own original sentence structure. A paraphrased source differs from a summarized source in that you focus on restating the ideas, not condensing them.

Again, it is important to check your paraphrase against the source material to make sure it is both accurate and original. Inexperienced writers sometimes use the thesaurus method of paraphrasing—that is, they simply rewrite the source material, replacing most of the words with synonyms. This constitutes a misuse of sources. A true paraphrase restates ideas using the writer’s own language and style.

In his draft, Jorge frequently paraphrased details from sources. At times, he needed to rewrite a sentence more than once to ensure he was paraphrasing ideas correctly. Read the passage from a website. Then read Jorge’s initial attempt at paraphrasing it, followed by the final version of his paraphrase.

Dieters nearly always get great results soon after they begin following a low-carbohydrate diet, but these results tend to taper off after the first few months, particularly because many dieters find it difficult to follow a low-carbohydrate diet plan consistently.

People usually see encouraging outcomes shortly after they go on a low-carbohydrate diet, but their progress slows down after a short while, especially because most discover that it is a challenge to adhere to the diet strictly (Heinz, 2009).

After reviewing the paraphrased sentence, Jorge realized he was following the original source too closely. He did not want to quote the full passage verbatim, so he again attempted to restate the idea in his own style.

Because it is hard for dieters to stick to a low-carbohydrate eating plan, the initial success of these diets is short-lived (Heinz, 2009).

On a separate sheet of paper, follow these steps to practice paraphrasing.

  • Choose an important idea or detail from your notes.
  • Without looking at the original source, restate the idea in your own words.
  • Check your paraphrase against the original text in the source. Make sure both your language and your sentence structure are original.
  • Revise your paraphrase if necessary.

Quoting Sources Directly

Most of the time, you will summarize or paraphrase source material instead of quoting directly. Doing so shows that you understand your research well enough to write about it confidently in your own words. However, direct quotes can be powerful when used sparingly and with purpose.

Quoting directly can sometimes help you make a point in a colorful way. If an author’s words are especially vivid, memorable, or well phrased, quoting them may help hold your reader’s interest. Direct quotations from an interviewee or an eyewitness may help you personalize an issue for readers. And when you analyze primary sources, such as a historical speech or a work of literature, quoting extensively is often necessary to illustrate your points. These are valid reasons to use quotations.

Less experienced writers, however, sometimes overuse direct quotations in a research paper because it seems easier than paraphrasing. At best, this reduces the effectiveness of the quotations. At worst, it results in a paper that seems haphazardly pasted together from outside sources. Use quotations sparingly for greater impact.

When you do choose to quote directly from a source, follow these guidelines:

  • Make sure you have transcribed the original statement accurately.
  • Represent the author’s ideas honestly. Quote enough of the original text to reflect the author’s point accurately.
  • Never use a stand-alone quotation. Always integrate the quoted material into your own sentence.
  • Use ellipses (…) if you need to omit a word or phrase. Use brackets [ ] if you need to replace a word or phrase.
  • Make sure any omissions or changed words do not alter the meaning of the original text. Omit or replace words only when absolutely necessary to shorten the text or to make it grammatically correct within your sentence.
  • Remember to include correctly formatted citations that follow the assigned style guide.

Jorge interviewed a dietician as part of his research, and he decided to quote her words in his paper. Read an excerpt from the interview and Jorge’s use of it, which follows.

Personally, I don’t really buy into all of the hype about low-carbohydrate miracle diets like Atkins and so on. Sure, for some people, they are great, but for most, any sensible eating and exercise plan would work just as well.

Registered dietician Dana Kwon (2010) admits, “Personally, I don’t really buy into all of the hype.…Sure, for some people, [low-carbohydrate diets] are great, but for most, any sensible eating and exercise plan would work just as well.”

Notice how Jorge smoothly integrated the quoted material by starting the sentence with an introductory phrase. His use of ellipses and brackets did not change the source’s meaning.

Documenting Source Material

Throughout the writing process, be scrupulous about documenting information taken from sources. The purpose of doing so is twofold:

  • To give credit to other writers or researchers for their ideas
  • To allow your reader to follow up and learn more about the topic if desired

You will cite sources within the body of your paper and at the end of the paper in your bibliography. For this assignment, you will use the citation format used by the American Psychological Association (also known as APA style). For information on the format used by the Modern Language Association (MLA style), see Chapter 13 "APA and MLA Documentation and Formatting" .

Citing Sources in the Body of Your Paper

In-text citations Instances in which use of source material is documented in the body text of the research paper. In-text citations must have corresponding sources listed in the references section. document your sources within the body of your paper. These include two vital pieces of information: the author’s name and the year the source material was published. When quoting a print source, also include in the citation the page number where the quoted material originally appears. The page number will follow the year in the in-text citation. Page numbers are necessary only when content has been directly quoted, not when it has been summarized or paraphrased.

Within a paragraph, this information may appear as part of your introduction to the material or as a parenthetical citation at the end of a sentence. Read the examples that follow. For more information about in-text citations for other source types, see Chapter 13 "APA and MLA Documentation and Formatting" .

Leibowitz (2008) found that low-carbohydrate diets often helped subjects with Type II diabetes maintain a healthy weight and control blood-sugar levels.

The introduction to the source material includes the author’s name followed by the year of publication in parentheses.

Low-carbohydrate diets often help subjects with Type II diabetes maintain a healthy weight and control blood-sugar levels (Leibowitz, 2008).

The parenthetical citation at the end of the sentence includes the author’s name, a comma, and the year the source was published. The period at the end of the sentence comes after the parentheses.

Creating a List of References

Each of the sources you cite in the body text will appear in a references list A list of sources used in a research paper that provides detailed bibliographical information. at the end of your paper. While in-text citations provide the most basic information about the source, your references section will include additional publication details. In general, you will include the following information:

  • The author’s last name followed by his or her first (and sometimes middle) initial
  • The year the source was published
  • The source title
  • For articles in periodicals, the full name of the periodical, along with the volume and issue number and the pages where the article appeared

Additional information may be included for different types of sources, such as online sources. For a detailed guide to APA or MLA citations, see Chapter 13 "APA and MLA Documentation and Formatting" . A sample reference list is provided with the final draft of Jorge’s paper later in this chapter.

Using Primary and Secondary Research

As you write your draft, be mindful of how you are using primary and secondary source material to support your points. Recall that primary sources present firsthand information. Secondary sources are one step removed from primary sources. They present a writer’s analysis or interpretation of primary source materials. How you balance primary and secondary source material in your paper will depend on the topic and assignment.

Using Primary Sources Effectively

Some types of research papers must use primary sources extensively to achieve their purpose. Any paper that analyzes a primary text or presents the writer’s own experimental research falls in this category. Here are a few examples:

  • A paper for a literature course analyzing several poems by Emily Dickinson
  • A paper for a political science course comparing televised speeches delivered by two presidential candidates
  • A paper for a communications course discussing gender biases in television commercials
  • A paper for a business administration course that discusses the results of a survey the writer conducted with local businesses to gather information about their work-from-home and flextime policies
  • A paper for an elementary education course that discusses the results of an experiment the writer conducted to compare the effectiveness of two different methods of mathematics instruction

For these types of papers, primary research is the main focus. If you are writing about a work (including nonprint works, such as a movie or a painting), it is crucial to gather information and ideas from the original work, rather than relying solely on others’ interpretations. And, of course, if you take the time to design and conduct your own field research, such as a survey, a series of interviews, or an experiment, you will want to discuss it in detail. For example, the interviews may provide interesting responses that you want to share with your reader.

Using Secondary Sources Effectively

For some assignments, it makes sense to rely more on secondary sources than primary sources. If you are not analyzing a text or conducting your own field research, you will need to use secondary sources extensively.

As much as possible, use secondary sources that are closely linked to primary research, such as a journal article presenting the results of the authors’ scientific study or a book that cites interviews and case studies. These sources are more reliable and add more value to your paper than sources that are further removed from primary research. For instance, a popular magazine article on junk-food addiction might be several steps removed from the original scientific study on which it is loosely based. As a result, the article may distort, sensationalize, or misinterpret the scientists’ findings.

Even if your paper is largely based on primary sources, you may use secondary sources to develop your ideas. For instance, an analysis of Alfred Hitchcock’s films would focus on the films themselves as a primary source, but might also cite commentary from critics. A paper that presents an original experiment would include some discussion of similar prior research in the field.

Jorge knew he did not have the time, resources, or experience needed to conduct original experimental research for his paper. Because he was relying on secondary sources to support his ideas, he made a point of citing sources that were not far removed from primary research.

Some sources could be considered primary or secondary sources, depending on the writer’s purpose for using them. For instance, if a writer’s purpose is to inform readers about how the No Child Left Behind legislation has affected elementary education, a Time magazine article on the subject would be a secondary source. However, suppose the writer’s purpose is to analyze how the news media has portrayed the effects of the No Child Left Behind legislation. In that case, articles about the legislation in news magazines like Time , Newsweek , and US News & World Report would be primary sources. They provide firsthand examples of the media coverage the writer is analyzing.

Avoiding Plagiarism

Your research paper presents your thinking about a topic, supported and developed by other people’s ideas and information. It is crucial to always distinguish between the two—as you conduct research, as you plan your paper, and as you write. Failure to do so can lead to plagiarism.

Intentional and Accidental Plagiarism

Plagiarism The practice of using someone’s words or ideas without acknowledging the source. Plagiarism may be deliberate or may occur unintentionally through careless use of source material. is the act of misrepresenting someone else’s work as your own. Sometimes a writer plagiarizes work on purpose—for instance, by purchasing an essay from a website and submitting it as original course work. In other cases, a writer may commit accidental plagiarism due to carelessness, haste, or misunderstanding. To avoid unintentional plagiarism, follow these guidelines:

  • Understand what types of information must be cited.
  • Understand what constitutes fair use of a source.
  • Keep source materials and notes carefully organized.
  • Follow guidelines for summarizing, paraphrasing, and quoting sources.

When to Cite

Any idea or fact taken from an outside source must be cited, in both the body of your paper and the references list. The only exceptions are facts or general statements that are common knowledge. Common-knowledge facts or general statements are commonly supported by and found in multiple sources. For example, a writer would not need to cite the statement that most breads, pastas, and cereals are high in carbohydrates; this is well known and well documented. However, if a writer explained in detail the differences among the chemical structures of carbohydrates, proteins, and fats, a citation would be necessary. When in doubt, cite.

In recent years, issues related to the fair use of sources have been prevalent in popular culture. Recording artists, for example, may disagree about the extent to which one has the right to sample another’s music. For academic purposes, however, the guidelines for fair use are reasonably straightforward.

Writers may quote from or paraphrase material from previously published works without formally obtaining the copyright holder’s permission. Fair use A legitimate use of brief quotations from source material to support and develop a writer’s ideas. means that the writer legitimately uses brief excerpts from source material to support and develop his or her own ideas. For instance, a columnist may excerpt a few sentences from a novel when writing a book review. However, quoting or paraphrasing another’s work at excessive length, to the extent that large sections of the writing are unoriginal, is not fair use.

As he worked on his draft, Jorge was careful to cite his sources correctly and not to rely excessively on any one source. Occasionally, however, he caught himself quoting a source at great length. In those instances, he highlighted the paragraph in question so that he could go back to it later and revise. Read the example, along with Jorge’s revision.

Heinz (2009) found that “subjects in the low-carbohydrate group (30% carbohydrates; 40% protein, 30% fat) had a mean weight loss of 10 kg (22 lbs) over a 4-month period.” These results were “noticeably better than results for subjects on a low-fat diet (45% carbohydrates, 35% protein, 20% fat)” whose average weight loss was only “7 kg (15.4 lbs) in the same period.” From this, it can be concluded that “low-carbohydrate diets obtain more rapid results.” Other researchers agree that “at least in the short term, patients following low-carbohydrate diets enjoy greater success” than those who follow alternative plans (Johnson & Crowe, 2010).

After reviewing the paragraph, Jorge realized that he had drifted into unoriginal writing. Most of the paragraph was taken verbatim from a single article. Although Jorge had enclosed the material in quotation marks, he knew it was not an appropriate way to use the research in his paper.

Low-carbohydrate diets may indeed be superior to other diet plans for short-term weight loss. In a study comparing low-carbohydrate diets and low-fat diets, Heinz (2009) found that subjects who followed a low-carbohydrate plan (30% of total calories) for 4 months lost, on average, about 3 kilograms more than subjects who followed a low-fat diet for the same time. Heinz concluded that these plans yield quick results, an idea supported by a similar study conducted by Johnson and Crowe (2010). What remains to be seen, however, is whether this initial success can be sustained for longer periods.

As Jorge revised the paragraph, he realized he did not need to quote these sources directly. Instead, he paraphrased their most important findings. He also made sure to include a topic sentence stating the main idea of the paragraph and a concluding sentence that transitioned to the next major topic in his essay.

Working with Sources Carefully

Disorganization and carelessness sometimes lead to plagiarism. For instance, a writer may be unable to provide a complete, accurate citation if he didn’t record bibliographical information. A writer may cut and paste a passage from a website into her paper and later forget where the material came from. A writer who procrastinates may rush through a draft, which easily leads to sloppy paraphrasing and inaccurate quotations. Any of these actions can create the appearance of plagiarism and lead to negative consequences.

Carefully organizing your time and notes is the best guard against these forms of plagiarism. Maintain a detailed working bibliography and thorough notes throughout the research process. Check original sources again to clear up any uncertainties. Allow plenty of time for writing your draft so there is no temptation to cut corners.

Citing other people’s work appropriately is just as important in the workplace as it is in school. If you need to consult outside sources to research a document you are creating, follow the general guidelines already discussed, as well as any industry-specific citation guidelines. For more extensive use of others’ work—for instance, requesting permission to link to another company’s website on your own corporate website—always follow your employer’s established procedures.

Academic Integrity

The concepts and strategies discussed in this section of Chapter 12 "Writing a Research Paper" connect to a larger issue—academic integrity. You maintain your integrity as a member of an academic community by representing your work and others’ work honestly and by using other people’s work only in legitimately accepted ways. It is a point of honor taken seriously in every academic discipline and career field.

Academic integrity violations have serious educational and professional consequences. Even when cheating and plagiarism go undetected, they still result in a student’s failure to learn necessary research and writing skills. Students who are found guilty of academic integrity violations face consequences ranging from a failing grade to expulsion from the university. Employees may be fired for plagiarism and do irreparable damage to their professional reputation. In short, it is never worth the risk.

Key Takeaways

  • An effective research paper focuses on the writer’s ideas. The introduction and conclusion present and revisit the writer’s thesis. The body of the paper develops the thesis and related points with information from research.
  • Ideas and information taken from outside sources must be cited in the body of the paper and in the references section.
  • Material taken from sources should be used to develop the writer’s ideas. Summarizing and paraphrasing are usually most effective for this purpose.
  • A summary concisely restates the main ideas of a source in the writer’s own words.
  • A paraphrase restates ideas from a source using the writer’s own words and sentence structures.
  • Direct quotations should be used sparingly. Ellipses and brackets must be used to indicate words that were omitted or changed for conciseness or grammatical correctness.
  • Always represent material from outside sources accurately.
  • Plagiarism has serious academic and professional consequences. To avoid accidental plagiarism, keep research materials organized, understand guidelines for fair use and appropriate citation of sources, and review the paper to make sure these guidelines are followed.

12.2 Developing a Final Draft of a Research Paper

  • Revise your paper to improve organization and cohesion.
  • Determine an appropriate style and tone for your paper.
  • Revise to ensure that your tone is consistent.
  • Edit your paper to ensure that language, citations, and formatting are correct.

Given all the time and effort you have put into your research project, you will want to make sure that your final draft represents your best work. This requires taking the time to revise and edit your paper carefully.

You may feel like you need a break from your paper before you revise and edit it. That is understandable—but leave yourself with enough time to complete this important stage of the writing process. In this section, you will learn the following specific strategies that are useful for revising and editing a research paper:

  • How to evaluate and improve the overall organization and cohesion
  • How to maintain an appropriate style and tone
  • How to use checklists to identify and correct any errors in language, citations, and formatting

Revising Your Paper: Organization and Cohesion

When writing a research paper, it is easy to become overly focused on editorial details, such as the proper format for bibliographical entries. These details do matter. However, before you begin to address them, it is important to spend time reviewing and revising the content of the paper.

A good research paper is both organized and cohesive. Organization In writing, a quality that describes the paper proceeding logically from the introduction to the body paragraphs to the conclusion. means that your argument flows logically from one point to the next. Cohesion In writing, a quality that describes the elements of a paper working together smoothly and naturally. means that the elements of your paper work together smoothly and naturally. In a cohesive research paper, information from research is seamlessly integrated with the writer’s ideas.

Revise to Improve Organization

When you revise to improve organization, you look at the flow of ideas throughout the essay as a whole and within individual paragraphs. You check to see that your essay moves logically from the introduction to the body paragraphs to the conclusion, and that each section reinforces your thesis. Use Checklist 12.1 to help you.

Checklist 12.1

Revision: Organization

At the essay level

  • Does my introduction proceed clearly from the opening to the thesis?
  • Does each body paragraph have a clear main idea that relates to the thesis?
  • Do the main ideas in the body paragraphs flow in a logical order? Is each paragraph connected to the one before it?
  • Do I need to add or revise topic sentences or transitions to make the overall flow of ideas clearer?
  • Does my conclusion summarize my main ideas and revisit my thesis?

At the paragraph level

  • Does the topic sentence clearly state the main idea?
  • Do the details in the paragraph relate to the main idea?
  • Do I need to recast any sentences or add transitions to improve the flow of sentences?

Jorge reread his draft paragraph by paragraph. As he read, he highlighted the main idea of each paragraph so he could see whether his ideas proceeded in a logical order. For the most part, the flow of ideas was clear. However, he did notice that one paragraph did not have a clear main idea. It interrupted the flow of the writing. During revision, Jorge added a topic sentence that clearly connected the paragraph to the one that had preceded it. He also added transitions to improve the flow of ideas from sentence to sentence.

Read the following paragraphs twice, the first time without Jorge’s changes, and the second time with them.

research body

Follow these steps to begin revising your paper’s overall organization.

  • Print out a hard copy of your paper.
  • Read your paper paragraph by paragraph. Highlight your thesis and the topic sentence of each paragraph.
  • Using the thesis and topic sentences as starting points, outline the ideas you presented—just as you would do if you were outlining a chapter in a textbook. Do not look at the outline you created during prewriting. You may write in the margins of your draft or create a formal outline on a separate sheet of paper.
  • Next, reread your paper more slowly, looking for how ideas flow from sentence to sentence. Identify places where adding a transition or recasting a sentence would make the ideas flow more logically.
  • Review the topics on your outline. Is there a logical flow of ideas? Identify any places where you may need to reorganize ideas.
  • Begin to revise your paper to improve organization. Start with any major issues, such as needing to move an entire paragraph. Then proceed to minor revisions, such as adding a transitional phrase or tweaking a topic sentence so it connects ideas more clearly.

Collaboration

Please share your paper with a classmate. Repeat the six steps and take notes on a separate piece of paper. Share and compare notes.

Writers choose transitions carefully to show the relationships between ideas—for instance, to make a comparison or elaborate on a point with examples. Make sure your transitions suit your purpose and avoid overusing the same ones. For an extensive list of transitions, see Chapter 8 "The Writing Process: How Do I Begin?" , Section 8.4 "Revising and Editing" .

Revise to Improve Cohesion

When you revise to improve cohesion, you analyze how the parts of your paper work together. You look for anything that seems awkward or out of place. Revision may involve deleting unnecessary material or rewriting parts of the paper so that the out-of-place material fits in smoothly.

In a research paper, problems with cohesion usually occur when a writer has trouble integrating source material. If facts or quotations have been awkwardly dropped into a paragraph, they distract or confuse the reader instead of working to support the writer’s point. Overusing paraphrased and quoted material has the same effect. Use Checklist 12.2 to review your essay for cohesion.

Checklist 12.2

Revision: Cohesion

  • Does the opening of the paper clearly connect to the broader topic and thesis? Make sure entertaining quotes or anecdotes serve a purpose.
  • Have I included support from research for each main point in the body of my paper?
  • Have I included introductory material before any quotations? Quotations should never stand alone in a paragraph.
  • Does paraphrased and quoted material clearly serve to develop my own points?
  • Do I need to add to or revise parts of the paper to help the reader understand how certain information from a source is relevant?
  • Are there any places where I have overused material from sources?
  • Does my conclusion make sense based on the rest of the paper? Make sure any new questions or suggestions in the conclusion are clearly linked to earlier material.

As Jorge reread his draft, he looked to see how the different pieces fit together to prove his thesis. He realized that some of his supporting information needed to be integrated more carefully and decided to omit some details entirely. Read the following paragraph, first without Jorge’s revisions and then with them.

research body

Jorge decided that his comment about pizza and birthday cake came across as subjective and was not necessary to make his point, so he deleted it. He also realized that the quotation at the end of the paragraph was awkward and ineffective. How would his readers know who Kwon was or why her opinion should be taken seriously? Adding an introductory phrase helped Jorge integrate this quotation smoothly and establish the credibility of his source.

Follow these steps to begin revising your paper to improve cohesion.

  • Print out a hard copy of your paper, or work with your printout from Note 12.33 "Exercise 1" .
  • Read the body paragraphs of your paper first. Each time you come to a place that cites information from sources, ask yourself what purpose this information serves. Check that it helps support a point and that it is clearly related to the other sentences in the paragraph.
  • Identify unnecessary information from sources that you can delete.
  • Identify places where you need to revise your writing so that readers understand the significance of the details cited from sources.
  • Skim the body paragraphs once more, looking for any paragraphs that seem packed with citations. Review these paragraphs carefully for cohesion.
  • Review your introduction and conclusion. Make sure the information presented works with ideas in the body of the paper.
  • Revise the places you identified in your paper to improve cohesion.

Please exchange papers with a classmate. Complete step four. On a separate piece of paper, note any areas that would benefit from clarification. Return and compare notes.

Understanding cohesion can also benefit you in the workplace, especially when you have to write and deliver a presentation. Speakers sometimes rely on cute graphics or funny quotations to hold their audience’s attention. If you choose to use these elements, make sure they work well with the substantive content of your presentation. For example, if you are asked to give a financial presentation, and the financial report shows that the company lost money, funny illustrations would not be relevant or appropriate for the presentation.

Using a Consistent Style and Tone

Once you are certain that the content of your paper fulfills your purpose, you can begin revising to improve style The unique way a writer uses language, which encompasses choices about sentence structure and word selection. and tone In writing, the attitude a writer conveys toward the subject and the audience. . Together, your style and tone create the voice of your paper, or how you come across to readers. Style refers to the way you use language as a writer—the sentence structures you use and the word choices you make. Tone is the attitude toward your subject and audience that you convey through your word choice.

Determining an Appropriate Style and Tone

Although accepted writing styles will vary within different disciplines, the underlying goal is the same—to come across to your readers as a knowledgeable, authoritative guide. Writing about research is like being a tour guide who walks readers through a topic. A stuffy, overly formal tour guide can make readers feel put off or intimidated. Too much informality or humor can make readers wonder whether the tour guide really knows what he or she is talking about. Extreme or emotionally charged language comes across as unbalanced.

To help prevent being overly formal or informal, determine an appropriate style and tone at the beginning of the research process. Consider your topic and audience because these can help dictate style and tone. For example, a paper on new breakthroughs in cancer research should be more formal than a paper on ways to get a good night’s sleep.

A strong research paper comes across as straightforward, appropriately academic, and serious. It is generally best to avoid writing in the first person, as this can make your paper seem overly subjective and opinion based. Use Checklist 12.3 on style to review your paper for other issues that affect style and tone. You can check for consistency at the end of the writing process. Checking for consistency is discussed later in this section.

Checklist 12.3

  • My paper avoids excessive wordiness.
  • My sentences are varied in length and structure.
  • I have avoided using first-person pronouns such as I and we .
  • I have used the active voice whenever possible.
  • I have defined specialized terms that might be unfamiliar to readers.
  • I have used clear, straightforward language whenever possible and avoided unnecessary jargon.
  • My paper states my point of view using a balanced tone—neither too indecisive nor too forceful.

Word Choice

Note that word choice is an especially important aspect of style. In addition to checking the points noted on Checklist 12.3, review your paper to make sure your language is precise, conveys no unintended connotations, and is free of biases. Here are some of the points to check for:

  • Vague or imprecise terms
  • Repetition of the same phrases (“Smith states…, Jones states…”) to introduce quoted and paraphrased material (For a full list of strong verbs to use with in-text citations, see Chapter 13 "APA and MLA Documentation and Formatting" .)
  • Exclusive use of masculine pronouns or awkward use of he or she
  • Use of language with negative connotations, such as haughty or ridiculous
  • Use of outdated or offensive terms to refer to specific ethnic, racial, or religious groups

Using plural nouns and pronouns or recasting a sentence can help you keep your language gender neutral while avoiding awkwardness. Consider the following examples.

  • Gender-biased: When a writer cites a source in the body of his paper, he must list it on his references page.
  • Awkward: When a writer cites a source in the body of his or her paper, he or she must list it on his or her references page.
  • Improved: Writers must list any sources cited in the body of a paper on the references page.

Keeping Your Style Consistent

As you revise your paper, make sure your style is consistent throughout. Look for instances where a word, phrase, or sentence just does not seem to fit with the rest of the writing. It is best to reread for style after you have completed the other revisions so that you are not distracted by any larger content issues. Revising strategies you can use include the following:

  • Read your paper aloud. Sometimes your ears catch inconsistencies that your eyes miss.
  • Share your paper with another reader whom you trust to give you honest feedback. It is often difficult to evaluate one’s own style objectively—especially in the final phase of a challenging writing project. Another reader may be more likely to notice instances of wordiness, confusing language, or other issues that affect style and tone.
  • Line-edit your paper slowly, sentence by sentence. You may even wish to use a sheet of paper to cover everything on the page except the paragraph you are editing—that forces you to read slowly and carefully. Mark any areas where you notice problems in style or tone, and then take time to rework those sections.

On reviewing his paper, Jorge found that he had generally used an appropriately academic style and tone. However, he noticed one glaring exception—his first paragraph. He realized there were places where his overly informal writing could come across as unserious or, worse, disparaging. Revising his word choice and omitting a humorous aside helped Jorge maintain a consistent tone. Read his revisions.

research body

Using Checklist 12.3, line-edit your paper. You may use either of these techniques:

  • Print out a hard copy of your paper, or work with your printout from Note 12.33 "Exercise 1" . Read it line by line. Check for the issues noted on Checklist 12.3, as well as any other aspects of your writing style you have previously identified as areas for improvement. Mark any areas where you notice problems in style or tone, and then take time to rework those sections.
  • If you prefer to work with an electronic document, use the menu options in your word-processing program to enlarge the text to 150 or 200 percent of the original size. Make sure the type is large enough that you can focus on only one paragraph at a time. Read the paper line by line as described in step 1. Highlight any areas where you notice problems in style or tone, and then take time to rework those sections.

Please exchange papers with a classmate. On a separate piece of paper, note places where the essay does not seem to flow or you have questions about what was written. Return the essay and compare notes.

Editing Your Paper

After revising your paper to address problems in content or style, you will complete one final editorial review. Perhaps you already have caught and corrected minor mistakes during previous revisions. Nevertheless, give your draft a final edit to make sure it is error-free. Your final edit should focus on two broad areas:

  • Errors in grammar, mechanics, usage, and spelling
  • Errors in citing and formatting sources

For in-depth information on these two topics, see Chapter 2 "Writing Basics: What Makes a Good Sentence?" and Chapter 13 "APA and MLA Documentation and Formatting" .

Correcting Errors

Given how much work you have put into your research paper, you will want to check for any errors that could distract or confuse your readers. Using the spell-checking feature in your word-processing program can be helpful—but this should not replace a full, careful review of your document. Be sure to check for any errors that may have come up frequently for you in the past. Use Checklist 12.4 to help you as you edit:

Checklist 12.4

Grammar, Mechanics, Punctuation, Usage, and Spelling

  • My paper is free of grammatical errors, such as errors in subject-verb agreement and sentence fragments. (For additional guidance on grammar, see Chapter 2 "Writing Basics: What Makes a Good Sentence?" .)
  • My paper is free of errors in punctuation and mechanics, such as misplaced commas or incorrectly formatted source titles. (For additional guidance on punctuation and mechanics, see Chapter 3 "Punctuation" .)
  • My paper is free of common usage errors, such as alot and alright . (For additional guidance on correct usage, see Chapter 4 "Working with Words: Which Word Is Right?" .)
  • My paper is free of spelling errors. I have proofread my paper for spelling in addition to using the spell-checking feature in my word-processing program.
  • I have checked my paper for any editing errors that I know I tend to make frequently.

Checking Citations and Formatting

When editing a research paper, it is also important to check that you have cited sources properly and formatted your document according to the specified guidelines. There are two reasons for this. First and foremost, citing sources correctly ensures that you have given proper credit to other people for ideas and information that helped you in your work. Second, using correct formatting establishes your paper as one student’s contribution to the work developed by and for a larger academic community. Increasingly, American Psychological Association (APA) style guidelines are the standard for many academic fields. Modern Language Association (MLA) is also a standard style in many fields. Use Checklist 12.5 to help you check citations and formatting.

Checklist 12.5

Citations and Formatting

  • Within the body of my paper, each fact or idea taken from a source is credited to the correct source.
  • Each in-text citation includes the source author’s name (or, where applicable, the organization name or source title) and year of publication. I have used the correct format of in-text and parenthetical citations.
  • Each source cited in the body of my paper has a corresponding entry in the references section of my paper.
  • My references section includes a heading and double-spaced, alphabetized entries.
  • Each entry in my references section is indented on the second line and all subsequent lines.
  • Each entry in my references section includes all the necessary information for that source type, in the correct sequence and format.
  • My paper includes a title page.
  • My paper includes a running head.
  • The margins of my paper are set at one inch. Text is double spaced and set in a standard 12-point font.

For detailed guidelines on APA and MLA citation and formatting, see Chapter 13 "APA and MLA Documentation and Formatting" .

Following APA or MLA citation and formatting guidelines may require time and effort. However, it is good practice for learning how to follow accepted conventions in any professional field. Many large corporations create a style manual with guidelines for editing and formatting documents produced by that corporation. Employees follow the style manual when creating internal documents and documents for publication.

During the process of revising and editing, Jorge made changes in the content and style of his paper. He also gave the paper a final review to check for overall correctness and, particularly, correct APA or MLA citations and formatting. Read the final draft of his paper.

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  • Organization in a research paper means that the argument proceeds logically from the introduction to the body to the conclusion. It flows logically from one point to the next. When revising a research paper, evaluate the organization of the paper as a whole and the organization of individual paragraphs.
  • In a cohesive research paper, the elements of the paper work together smoothly and naturally. When revising a research paper, evaluate its cohesion. In particular, check that information from research is smoothly integrated with your ideas.
  • An effective research paper uses a style and tone that are appropriately academic and serious. When revising a research paper, check that the style and tone are consistent throughout.
  • Editing a research paper involves checking for errors in grammar, mechanics, punctuation, usage, spelling, citations, and formatting.

12.3 Writing a Research Paper: End-of-Chapter Exercises

  • In this chapter, you learned strategies for generating and narrowing a topic for a research paper. Brainstorm to create a list of five general topics of personal or professional interest to you that you would like to research. Then use freewriting and preliminary research to narrow three of these topics to manageable size for a five- to seven-page research paper. Save your list of topics in a print or electronic file and add to it periodically as you identify additional areas of interest. Use your topic list as a starting point the next time a research paper is assigned.

Working with one of the topics you just identified, use the research skills you learned in this chapter to locate three to five potentially useful print or electronic sources of information about the topic. Create a list that includes the following:

  • One subject-specific periodicals database likely to include relevant articles on your topic
  • Two articles about your topic written for an educated general audience
  • At least one article about your topic written for an audience with specialized knowledge

In real-life and work-related contexts, people consult a wide range of different information sources every day, without always making conscious judgments about whether the source is reliable and why. Identify one media source of information you use at least once a week—for instance, a website you visit regularly, or a newspaper or magazine to which you subscribe. Write two paragraphs explaining the following:

  • What topics you learn about by reading or viewing this source
  • Whether you consider this source reliable and why

In addressing the latter point, be sure to consider details that help you evaluate the source’s credibility and reputability, as well as the presence or absence of bias.

Different professional communities develop their own standards about the writing style people in that community use when creating documents to share with others. In some cases, these standards may apply to a very broad group of professionals—for example, researchers in many different social sciences use APA style in academic writing. MLA style is commonly used in the humanities, including English classes. In other cases, style guidelines are specific to a particular company or organization. Find a document, such as a newsletter or brochure, that was produced by an organization to which you belong. (Make sure it is a document you have permission to share.) Review the document and answer the following questions:

  • What are the purpose, intended audience, and message of this document?
  • How does the writing style function to fulfill the purpose, appeal to a particular audience, and convey a message? Consider elements of style, such as word choice, the use of active or passive voice, sentence length, and sentence structure. If your document includes graphics, consider their effectiveness as well.
  • Are there any places where the style is inconsistent?
  • Is the writing style of this document effective for achieving the document’s purpose? Why or why not? If it is not effective, explain why.

Writing the Body Of the Paper

Ask these questions:

What is it?

It is putting all of your research together in a format that you can present to people.

There are many different ways to put together and present your thesis statement and supporting evidence.

Once you have an '); Activate();" onmouseout="deActivate()">outline that you like, you will be able to link your ideas and evidence either with sentences and paragraphs, visuals, sounds, movements, or a combination of any of these.

This tip sheet will focus on the written research paper, which is the format most commonly required.

If you have some flexibility in how you present your project, see Alternative Formats for the Presentation of Research Projects.

How do I begin to write the body of a research paper?

  • You will continue in this manner until you reach the conclusion section of your outline.
:

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How to Write a Research Paper

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The research paper writing process

In the first article of this two part series, we discussed how to research a term paper . In this article, we will discuss how to write a term or research paper.

Write your thesis statement

After you have spent some time finding your sources and absorbing the information, you should then be able to come up with a thesis statement that tells the reader how you will interpret the significance of the subject matter. This statement is a road map for the research paper, telling the reader what to expect. It usually consists of a single sentence somewhere in your first paragraph and makes a claim that others might later dispute!

For optimal organization, take the time to write an outline that indicates the main aspects to be discussed. This includes deciding on the order of your sub-topics and which key points you will use as evidence to support your position.

Keep the body of your research paper in good shape

The body is the largest part of a research paper; in it you collect and arrange evidence that will persuade the reader of your argument. It should, therefore, have a logical organization. If the paper is long, it is a good idea to partition the body into sections using headings and sub-headings. This includes using parenthetical citations when referencing another author's work in the body of your text.

Sometimes the beginning isn't the best place to start...

Write the introduction and conclusion of your research paper last in order to ensure accuracy. The introduction is the key to letting your readers know where you are headed and what you hope to accomplish. Remember that while the organization of your research paper may be clear to you, it may not necessarily be clear to your readers. Therefore, the introduction should acquaint them with the journey ahead, making it easier for them to understand what follows and helping to improve their evaluation of your work. Tell your readers in concise terms what the subject of the paper is, what it is that you hope to find out, and how you will go about doing so.

Encapsulating your findings in the conclusion is not the only place in the research paper where you make your voice heard. Your analysis should appear throughout. A common ESL mistake is reciting facts in the body of their essay and then waiting until the conclusion to say what they mean. Good research papers bring data, events, and other material together, interpreting the facts throughout. The conclusion should summarize what you have said in the body and should stress the evidence that supports your analysis.

Don't forget your references

Once your research paper is finished, compile your reference list. This is an alphabetical listing of all the sources you referenced in the body of your paper. If you made notes about your sources, this task should be straightforward. Be sure to follow whatever style guide your professor or school recommends. We have an example APA Reference page and an example MLA Works Cited for your reference.

Edit your research paper to ensure clarity

Once you have the pieces of your research paper in place, it's time to polish, polish, polish! Double-check everything. Ensure you have correctly cited your sources, checked your spelling and grammar, and re-read your paper several times, checking for sense, logical structure, and organization. Readers will judge your paper not only on the quality of research, but also on the quality of the writing.

Ta da! You've done it—your research paper is complete! Just think about what you've learned: not just about your subject, but about the whole investigative process.

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  • A Research Guide
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Research Paper Body Paragraph Structure

Introduction.

  • Referrences
  • Ways to start paragraph
  • Step by step guide
  • Research paragraph examples

Research Paper Body Paragraph Structure

Learning the basics of a paragraph structure

  • Title (cover page).
  • Introduction.
  • Literature review.
  • Research methodology.
  • Data analysis.
  • Conclusion.
  • Reference page.

5 winning ways to start a body paragraph

  • Topic Sentence : it should provide a clear focus and introduce the specific aspect you will discuss. For example, “One key factor influencing climate change is…”.
  • Opening Statement: grab your readers’ attention with a thought-provoking or surprising statement related to your topic. For instance, “The alarming increase in global temperatures has reached a critical point, demanding immediate action.”
  • Quotation: find a relevant quote from a reputable source. It won’t only add credibility to your research but will also engage the reader right from the start.
  • Anecdote or example: start your academic paragraph with a funny story or a real-world example that illustrates the significance of your research topic.
  • Background information : provide a brief background or context for the topic you are about to discuss. For example, “In recent years, the prevalence of cyber-attacks has skyrocketed, posing a severe threat to individuals, organizations, and even national security.”

A step-by-step guide to starting a concise body paragraph

Step 1: introduce the main point or argument., step 2: provide evidence or examples., step 3: explain and analyze., step 4: connect to the main argument., step 5: review and revise., flawless body paragraph example: how does it look.

  • Topic Sentence: Rising global temperatures have significant implications for ecosystems and biodiversity.
  • Evidence/Example 1: According to a study by the Intergovernmental Panel on Climate Change (IPCC), global average temperatures have increased by 1.1 degrees Celsius since pre-industrial times (IPCC, 2021). This temperature rise has led to melting polar ice caps and glaciers, rising sea levels, and coastal erosion (Smith et al., 2019).
  • Explanation/Analysis 1: The significant increase in global temperatures has caused observable changes in the Earth’s physical environment. The melting of polar ice caps not only contributes to the rise in sea levels but also disrupts marine ecosystems.
  • Evidence/Example 2: In addition to the loss of coastal habitats, higher temperatures have also resulted in shifts in the geographical distribution of species. Research by Parmesan and Yohe (2019) indicates that many plant and animal species have altered their ranges and migration patterns in response to changing climate conditions.
  • Explanation/Analysis 2: The observed shifts in species distribution highlight the vulnerability of ecosystems to climate change. As temperature zone modification, species that cannot adapt or migrate to suitable habitats may face reduced reproductive success and increased risk of extinction.
  • Connect to the main argument: These examples demonstrate that the rising global temperatures associated with climate change have profound implications for ecosystems and biodiversity.

The bottom line

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Writing a Research Paper

This page lists some of the stages involved in writing a library-based research paper.

Although this list suggests that there is a simple, linear process to writing such a paper, the actual process of writing a research paper is often a messy and recursive one, so please use this outline as a flexible guide.

Discovering, Narrowing, and Focusing a Researchable Topic

  • Try to find a topic that truly interests you
  • Try writing your way to a topic
  • Talk with your course instructor and classmates about your topic
  • Pose your topic as a question to be answered or a problem to be solved

Finding, Selecting, and Reading Sources

You will need to look at the following types of sources:

  • library catalog, periodical indexes, bibliographies, suggestions from your instructor
  • primary vs. secondary sources
  • journals, books, other documents

Grouping, Sequencing, and Documenting Information

The following systems will help keep you organized:

  • a system for noting sources on bibliography cards
  • a system for organizing material according to its relative importance
  • a system for taking notes

Writing an Outline and a Prospectus for Yourself

Consider the following questions:

  • What is the topic?
  • Why is it significant?
  • What background material is relevant?
  • What is my thesis or purpose statement?
  • What organizational plan will best support my purpose?

Writing the Introduction

In the introduction you will need to do the following things:

  • present relevant background or contextual material
  • define terms or concepts when necessary
  • explain the focus of the paper and your specific purpose
  • reveal your plan of organization

Writing the Body

  • Use your outline and prospectus as flexible guides
  • Build your essay around points you want to make (i.e., don’t let your sources organize your paper)
  • Integrate your sources into your discussion
  • Summarize, analyze, explain, and evaluate published work rather than merely reporting it
  • Move up and down the “ladder of abstraction” from generalization to varying levels of detail back to generalization

Writing the Conclusion

  • If the argument or point of your paper is complex, you may need to summarize the argument for your reader.
  • If prior to your conclusion you have not yet explained the significance of your findings or if you are proceeding inductively, use the end of your paper to add your points up, to explain their significance.
  • Move from a detailed to a general level of consideration that returns the topic to the context provided by the introduction.
  • Perhaps suggest what about this topic needs further research.

Revising the Final Draft

  • Check overall organization : logical flow of introduction, coherence and depth of discussion in body, effectiveness of conclusion.
  • Paragraph level concerns : topic sentences, sequence of ideas within paragraphs, use of details to support generalizations, summary sentences where necessary, use of transitions within and between paragraphs.
  • Sentence level concerns: sentence structure, word choices, punctuation, spelling.
  • Documentation: consistent use of one system, citation of all material not considered common knowledge, appropriate use of endnotes or footnotes, accuracy of list of works cited.

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Parts of a Research Paper

One of the most important aspects of science is ensuring that you get all the parts of the written research paper in the right order.

This article is a part of the guide:

  • Outline Examples
  • Example of a Paper
  • Write a Hypothesis
  • Introduction

Browse Full Outline

  • 1 Write a Research Paper
  • 2 Writing a Paper
  • 3.1 Write an Outline
  • 3.2 Outline Examples
  • 4.1 Thesis Statement
  • 4.2 Write a Hypothesis
  • 5.2 Abstract
  • 5.3 Introduction
  • 5.4 Methods
  • 5.5 Results
  • 5.6 Discussion
  • 5.7 Conclusion
  • 5.8 Bibliography
  • 6.1 Table of Contents
  • 6.2 Acknowledgements
  • 6.3 Appendix
  • 7.1 In Text Citations
  • 7.2 Footnotes
  • 7.3.1 Floating Blocks
  • 7.4 Example of a Paper
  • 7.5 Example of a Paper 2
  • 7.6.1 Citations
  • 7.7.1 Writing Style
  • 7.7.2 Citations
  • 8.1.1 Sham Peer Review
  • 8.1.2 Advantages
  • 8.1.3 Disadvantages
  • 8.2 Publication Bias
  • 8.3.1 Journal Rejection
  • 9.1 Article Writing
  • 9.2 Ideas for Topics

You may have finished the best research project on earth but, if you do not write an interesting and well laid out paper, then nobody is going to take your findings seriously.

The main thing to remember with any research paper is that it is based on an hourglass structure. It begins with general information and undertaking a literature review , and becomes more specific as you nail down a research problem and hypothesis .

Finally, it again becomes more general as you try to apply your findings to the world at general.

Whilst there are a few differences between the various disciplines, with some fields placing more emphasis on certain parts than others, there is a basic underlying structure.

These steps are the building blocks of constructing a good research paper. This section outline how to lay out the parts of a research paper, including the various experimental methods and designs.

The principles for literature review and essays of all types follow the same basic principles.

Reference List

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For many students, writing the introduction is the first part of the process, setting down the direction of the paper and laying out exactly what the research paper is trying to achieve.

For others, the introduction is the last thing written, acting as a quick summary of the paper. As long as you have planned a good structure for the parts of a research paper, both approaches are acceptable and it is a matter of preference.

A good introduction generally consists of three distinct parts:

  • You should first give a general presentation of the research problem.
  • You should then lay out exactly what you are trying to achieve with this particular research project.
  • You should then state your own position.

Ideally, you should try to give each section its own paragraph, but this will vary given the overall length of the paper.

1) General Presentation

Look at the benefits to be gained by the research or why the problem has not been solved yet. Perhaps nobody has thought about it, or maybe previous research threw up some interesting leads that the previous researchers did not follow up.

Another researcher may have uncovered some interesting trends, but did not manage to reach the significance level , due to experimental error or small sample sizes .

2) Purpose of the Paper

The research problem does not have to be a statement, but must at least imply what you are trying to find.

Many writers prefer to place the thesis statement or hypothesis here, which is perfectly acceptable, but most include it in the last sentences of the introduction, to give the reader a fuller picture.

3) A Statement of Intent From the Writer

The idea is that somebody will be able to gain an overall view of the paper without needing to read the whole thing. Literature reviews are time-consuming enough, so give the reader a concise idea of your intention before they commit to wading through pages of background.

In this section, you look to give a context to the research, including any relevant information learned during your literature review. You are also trying to explain why you chose this area of research, attempting to highlight why it is necessary. The second part should state the purpose of the experiment and should include the research problem. The third part should give the reader a quick summary of the form that the parts of the research paper is going to take and should include a condensed version of the discussion.

research body

This should be the easiest part of the paper to write, as it is a run-down of the exact design and methodology used to perform the research. Obviously, the exact methodology varies depending upon the exact field and type of experiment .

There is a big methodological difference between the apparatus based research of the physical sciences and the methods and observation methods of social sciences. However, the key is to ensure that another researcher would be able to replicate the experiment to match yours as closely as possible, but still keeping the section concise.

You can assume that anybody reading your paper is familiar with the basic methods, so try not to explain every last detail. For example, an organic chemist or biochemist will be familiar with chromatography, so you only need to highlight the type of equipment used rather than explaining the whole process in detail.

In the case of a survey , if you have too many questions to cover in the method, you can always include a copy of the questionnaire in the appendix . In this case, make sure that you refer to it.

This is probably the most variable part of any research paper, and depends on the results and aims of the experiment.

For quantitative research , it is a presentation of the numerical results and data, whereas for qualitative research it should be a broader discussion of trends, without going into too much detail.

For research generating a lot of results , then it is better to include tables or graphs of the analyzed data and leave the raw data in the appendix, so that a researcher can follow up and check your calculations.

A commentary is essential to linking the results together, rather than just displaying isolated and unconnected charts and figures.

It can be quite difficult to find a good balance between the results and the discussion section, because some findings, especially in a quantitative or descriptive experiment , will fall into a grey area. Try to avoid repeating yourself too often.

It is best to try to find a middle path, where you give a general overview of the data and then expand on it in the discussion - you should try to keep your own opinions and interpretations out of the results section, saving that for the discussion later on.

This is where you elaborate on your findings, and explain what you found, adding your own personal interpretations.

Ideally, you should link the discussion back to the introduction, addressing each point individually.

It’s important to make sure that every piece of information in your discussion is directly related to the thesis statement , or you risk cluttering your findings. In keeping with the hourglass principle, you can expand on the topic later in the conclusion .

The conclusion is where you build on your discussion and try to relate your findings to other research and to the world at large.

In a short research paper, it may be a paragraph or two, or even a few lines.

In a dissertation, it may well be the most important part of the entire paper - not only does it describe the results and discussion in detail, it emphasizes the importance of the results in the field, and ties it in with the previous research.

Some research papers require a recommendations section, postulating the further directions of the research, as well as highlighting how any flaws affected the results. In this case, you should suggest any improvements that could be made to the research design .

No paper is complete without a reference list , documenting all the sources that you used for your research. This should be laid out according to APA , MLA or other specified format, allowing any interested researcher to follow up on the research.

One habit that is becoming more common, especially with online papers, is to include a reference to your own paper on the final page. Lay this out in MLA, APA and Chicago format, allowing anybody referencing your paper to copy and paste it.

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Organizing Your Social Sciences Research Paper

  • 4. The Introduction
  • Purpose of Guide
  • Design Flaws to Avoid
  • Independent and Dependent Variables
  • Glossary of Research Terms
  • Reading Research Effectively
  • Narrowing a Topic Idea
  • Broadening a Topic Idea
  • Extending the Timeliness of a Topic Idea
  • Academic Writing Style
  • Applying Critical Thinking
  • Choosing a Title
  • Making an Outline
  • Paragraph Development
  • Research Process Video Series
  • Executive Summary
  • The C.A.R.S. Model
  • Background Information
  • The Research Problem/Question
  • Theoretical Framework
  • Citation Tracking
  • Content Alert Services
  • Evaluating Sources
  • Primary Sources
  • Secondary Sources
  • Tiertiary Sources
  • Scholarly vs. Popular Publications
  • Qualitative Methods
  • Quantitative Methods
  • Insiderness
  • Using Non-Textual Elements
  • Limitations of the Study
  • Common Grammar Mistakes
  • Writing Concisely
  • Avoiding Plagiarism
  • Footnotes or Endnotes?
  • Further Readings
  • Generative AI and Writing
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  • Bibliography

The introduction leads the reader from a general subject area to a particular topic of inquiry. It establishes the scope, context, and significance of the research being conducted by summarizing current understanding and background information about the topic, stating the purpose of the work in the form of the research problem supported by a hypothesis or a set of questions, explaining briefly the methodological approach used to examine the research problem, highlighting the potential outcomes your study can reveal, and outlining the remaining structure and organization of the paper.

Key Elements of the Research Proposal. Prepared under the direction of the Superintendent and by the 2010 Curriculum Design and Writing Team. Baltimore County Public Schools.

Importance of a Good Introduction

Think of the introduction as a mental road map that must answer for the reader these four questions:

  • What was I studying?
  • Why was this topic important to investigate?
  • What did we know about this topic before I did this study?
  • How will this study advance new knowledge or new ways of understanding?

According to Reyes, there are three overarching goals of a good introduction: 1) ensure that you summarize prior studies about the topic in a manner that lays a foundation for understanding the research problem; 2) explain how your study specifically addresses gaps in the literature, insufficient consideration of the topic, or other deficiency in the literature; and, 3) note the broader theoretical, empirical, and/or policy contributions and implications of your research.

A well-written introduction is important because, quite simply, you never get a second chance to make a good first impression. The opening paragraphs of your paper will provide your readers with their initial impressions about the logic of your argument, your writing style, the overall quality of your research, and, ultimately, the validity of your findings and conclusions. A vague, disorganized, or error-filled introduction will create a negative impression, whereas, a concise, engaging, and well-written introduction will lead your readers to think highly of your analytical skills, your writing style, and your research approach. All introductions should conclude with a brief paragraph that describes the organization of the rest of the paper.

Hirano, Eliana. “Research Article Introductions in English for Specific Purposes: A Comparison between Brazilian, Portuguese, and English.” English for Specific Purposes 28 (October 2009): 240-250; Samraj, B. “Introductions in Research Articles: Variations Across Disciplines.” English for Specific Purposes 21 (2002): 1–17; Introductions. The Writing Center. University of North Carolina; “Writing Introductions.” In Good Essay Writing: A Social Sciences Guide. Peter Redman. 4th edition. (London: Sage, 2011), pp. 63-70; Reyes, Victoria. Demystifying the Journal Article. Inside Higher Education.

Structure and Writing Style

I.  Structure and Approach

The introduction is the broad beginning of the paper that answers three important questions for the reader:

  • What is this?
  • Why should I read it?
  • What do you want me to think about / consider doing / react to?

Think of the structure of the introduction as an inverted triangle of information that lays a foundation for understanding the research problem. Organize the information so as to present the more general aspects of the topic early in the introduction, then narrow your analysis to more specific topical information that provides context, finally arriving at your research problem and the rationale for studying it [often written as a series of key questions to be addressed or framed as a hypothesis or set of assumptions to be tested] and, whenever possible, a description of the potential outcomes your study can reveal.

These are general phases associated with writing an introduction: 1.  Establish an area to research by:

  • Highlighting the importance of the topic, and/or
  • Making general statements about the topic, and/or
  • Presenting an overview on current research on the subject.

2.  Identify a research niche by:

  • Opposing an existing assumption, and/or
  • Revealing a gap in existing research, and/or
  • Formulating a research question or problem, and/or
  • Continuing a disciplinary tradition.

3.  Place your research within the research niche by:

  • Stating the intent of your study,
  • Outlining the key characteristics of your study,
  • Describing important results, and
  • Giving a brief overview of the structure of the paper.

NOTE:   It is often useful to review the introduction late in the writing process. This is appropriate because outcomes are unknown until you've completed the study. After you complete writing the body of the paper, go back and review introductory descriptions of the structure of the paper, the method of data gathering, the reporting and analysis of results, and the conclusion. Reviewing and, if necessary, rewriting the introduction ensures that it correctly matches the overall structure of your final paper.

II.  Delimitations of the Study

Delimitations refer to those characteristics that limit the scope and define the conceptual boundaries of your research . This is determined by the conscious exclusionary and inclusionary decisions you make about how to investigate the research problem. In other words, not only should you tell the reader what it is you are studying and why, but you must also acknowledge why you rejected alternative approaches that could have been used to examine the topic.

Obviously, the first limiting step was the choice of research problem itself. However, implicit are other, related problems that could have been chosen but were rejected. These should be noted in the conclusion of your introduction. For example, a delimitating statement could read, "Although many factors can be understood to impact the likelihood young people will vote, this study will focus on socioeconomic factors related to the need to work full-time while in school." The point is not to document every possible delimiting factor, but to highlight why previously researched issues related to the topic were not addressed.

Examples of delimitating choices would be:

  • The key aims and objectives of your study,
  • The research questions that you address,
  • The variables of interest [i.e., the various factors and features of the phenomenon being studied],
  • The method(s) of investigation,
  • The time period your study covers, and
  • Any relevant alternative theoretical frameworks that could have been adopted.

Review each of these decisions. Not only do you clearly establish what you intend to accomplish in your research, but you should also include a declaration of what the study does not intend to cover. In the latter case, your exclusionary decisions should be based upon criteria understood as, "not interesting"; "not directly relevant"; “too problematic because..."; "not feasible," and the like. Make this reasoning explicit!

NOTE:   Delimitations refer to the initial choices made about the broader, overall design of your study and should not be confused with documenting the limitations of your study discovered after the research has been completed.

ANOTHER NOTE: Do not view delimitating statements as admitting to an inherent failing or shortcoming in your research. They are an accepted element of academic writing intended to keep the reader focused on the research problem by explicitly defining the conceptual boundaries and scope of your study. It addresses any critical questions in the reader's mind of, "Why the hell didn't the author examine this?"

III.  The Narrative Flow

Issues to keep in mind that will help the narrative flow in your introduction :

  • Your introduction should clearly identify the subject area of interest . A simple strategy to follow is to use key words from your title in the first few sentences of the introduction. This will help focus the introduction on the topic at the appropriate level and ensures that you get to the subject matter quickly without losing focus, or discussing information that is too general.
  • Establish context by providing a brief and balanced review of the pertinent published literature that is available on the subject. The key is to summarize for the reader what is known about the specific research problem before you did your analysis. This part of your introduction should not represent a comprehensive literature review--that comes next. It consists of a general review of the important, foundational research literature [with citations] that establishes a foundation for understanding key elements of the research problem. See the drop-down menu under this tab for " Background Information " regarding types of contexts.
  • Clearly state the hypothesis that you investigated . When you are first learning to write in this format it is okay, and actually preferable, to use a past statement like, "The purpose of this study was to...." or "We investigated three possible mechanisms to explain the...."
  • Why did you choose this kind of research study or design? Provide a clear statement of the rationale for your approach to the problem studied. This will usually follow your statement of purpose in the last paragraph of the introduction.

IV.  Engaging the Reader

A research problem in the social sciences can come across as dry and uninteresting to anyone unfamiliar with the topic . Therefore, one of the goals of your introduction is to make readers want to read your paper. Here are several strategies you can use to grab the reader's attention:

  • Open with a compelling story . Almost all research problems in the social sciences, no matter how obscure or esoteric , are really about the lives of people. Telling a story that humanizes an issue can help illuminate the significance of the problem and help the reader empathize with those affected by the condition being studied.
  • Include a strong quotation or a vivid, perhaps unexpected, anecdote . During your review of the literature, make note of any quotes or anecdotes that grab your attention because they can used in your introduction to highlight the research problem in a captivating way.
  • Pose a provocative or thought-provoking question . Your research problem should be framed by a set of questions to be addressed or hypotheses to be tested. However, a provocative question can be presented in the beginning of your introduction that challenges an existing assumption or compels the reader to consider an alternative viewpoint that helps establish the significance of your study. 
  • Describe a puzzling scenario or incongruity . This involves highlighting an interesting quandary concerning the research problem or describing contradictory findings from prior studies about a topic. Posing what is essentially an unresolved intellectual riddle about the problem can engage the reader's interest in the study.
  • Cite a stirring example or case study that illustrates why the research problem is important . Draw upon the findings of others to demonstrate the significance of the problem and to describe how your study builds upon or offers alternatives ways of investigating this prior research.

NOTE:   It is important that you choose only one of the suggested strategies for engaging your readers. This avoids giving an impression that your paper is more flash than substance and does not distract from the substance of your study.

Freedman, Leora  and Jerry Plotnick. Introductions and Conclusions. University College Writing Centre. University of Toronto; Introduction. The Structure, Format, Content, and Style of a Journal-Style Scientific Paper. Department of Biology. Bates College; Introductions. The Writing Center. University of North Carolina; Introductions. The Writer’s Handbook. Writing Center. University of Wisconsin, Madison; Introductions, Body Paragraphs, and Conclusions for an Argument Paper. The Writing Lab and The OWL. Purdue University; “Writing Introductions.” In Good Essay Writing: A Social Sciences Guide . Peter Redman. 4th edition. (London: Sage, 2011), pp. 63-70; Resources for Writers: Introduction Strategies. Program in Writing and Humanistic Studies. Massachusetts Institute of Technology; Sharpling, Gerald. Writing an Introduction. Centre for Applied Linguistics, University of Warwick; Samraj, B. “Introductions in Research Articles: Variations Across Disciplines.” English for Specific Purposes 21 (2002): 1–17; Swales, John and Christine B. Feak. Academic Writing for Graduate Students: Essential Skills and Tasks . 2nd edition. Ann Arbor, MI: University of Michigan Press, 2004 ; Writing Your Introduction. Department of English Writing Guide. George Mason University.

Writing Tip

Avoid the "Dictionary" Introduction

Giving the dictionary definition of words related to the research problem may appear appropriate because it is important to define specific terminology that readers may be unfamiliar with. However, anyone can look a word up in the dictionary and a general dictionary is not a particularly authoritative source because it doesn't take into account the context of your topic and doesn't offer particularly detailed information. Also, placed in the context of a particular discipline, a term or concept may have a different meaning than what is found in a general dictionary. If you feel that you must seek out an authoritative definition, use a subject specific dictionary or encyclopedia [e.g., if you are a sociology student, search for dictionaries of sociology]. A good database for obtaining definitive definitions of concepts or terms is Credo Reference .

Saba, Robert. The College Research Paper. Florida International University; Introductions. The Writing Center. University of North Carolina.

Another Writing Tip

When Do I Begin?

A common question asked at the start of any paper is, "Where should I begin?" An equally important question to ask yourself is, "When do I begin?" Research problems in the social sciences rarely rest in isolation from history. Therefore, it is important to lay a foundation for understanding the historical context underpinning the research problem. However, this information should be brief and succinct and begin at a point in time that illustrates the study's overall importance. For example, a study that investigates coffee cultivation and export in West Africa as a key stimulus for local economic growth needs to describe the beginning of exporting coffee in the region and establishing why economic growth is important. You do not need to give a long historical explanation about coffee exports in Africa. If a research problem requires a substantial exploration of the historical context, do this in the literature review section. In your introduction, make note of this as part of the "roadmap" [see below] that you use to describe the organization of your paper.

Introductions. The Writing Center. University of North Carolina; “Writing Introductions.” In Good Essay Writing: A Social Sciences Guide . Peter Redman. 4th edition. (London: Sage, 2011), pp. 63-70.

Yet Another Writing Tip

Always End with a Roadmap

The final paragraph or sentences of your introduction should forecast your main arguments and conclusions and provide a brief description of the rest of the paper [the "roadmap"] that let's the reader know where you are going and what to expect. A roadmap is important because it helps the reader place the research problem within the context of their own perspectives about the topic. In addition, concluding your introduction with an explicit roadmap tells the reader that you have a clear understanding of the structural purpose of your paper. In this way, the roadmap acts as a type of promise to yourself and to your readers that you will follow a consistent and coherent approach to addressing the topic of inquiry. Refer to it often to help keep your writing focused and organized.

Cassuto, Leonard. “On the Dissertation: How to Write the Introduction.” The Chronicle of Higher Education , May 28, 2018; Radich, Michael. A Student's Guide to Writing in East Asian Studies . (Cambridge, MA: Harvard University Writing n. d.), pp. 35-37.

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Body Paragraphs

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Body paragraphs: Moving from general to specific information

Your paper should be organized in a manner that moves from general to specific information. Every time you begin a new subject, think of an inverted pyramid - The broadest range of information sits at the top, and as the paragraph or paper progresses, the author becomes more and more focused on the argument ending with specific, detailed evidence supporting a claim. Lastly, the author explains how and why the information she has just provided connects to and supports her thesis (a brief wrap-up or warrant).

This image shows an inverted pyramid that contains the following text. At the wide top of the pyramid, the text reads general information introduction, topic sentence. Moving down the pyramid to the narrow point, the text reads focusing direction of paper, telling. Getting more specific, showing. Supporting details, data. Conclusions and brief wrap up, warrant.

Moving from General to Specific Information

The four elements of a good paragraph (TTEB)

A good paragraph should contain at least the following four elements: T ransition, T opic sentence, specific E vidence and analysis, and a B rief wrap-up sentence (also known as a warrant ) –TTEB!

  • A T ransition sentence leading in from a previous paragraph to assure smooth reading. This acts as a hand-off from one idea to the next.
  • A T opic sentence that tells the reader what you will be discussing in the paragraph.
  • Specific E vidence and analysis that supports one of your claims and that provides a deeper level of detail than your topic sentence.
  • A B rief wrap-up sentence that tells the reader how and why this information supports the paper’s thesis. The brief wrap-up is also known as the warrant. The warrant is important to your argument because it connects your reasoning and support to your thesis, and it shows that the information in the paragraph is related to your thesis and helps defend it.

Supporting evidence (induction and deduction)

Induction is the type of reasoning that moves from specific facts to a general conclusion. When you use induction in your paper, you will state your thesis (which is actually the conclusion you have come to after looking at all the facts) and then support your thesis with the facts. The following is an example of induction taken from Dorothy U. Seyler’s Understanding Argument :

There is the dead body of Smith. Smith was shot in his bedroom between the hours of 11:00 p.m. and 2:00 a.m., according to the coroner. Smith was shot with a .32 caliber pistol. The pistol left in the bedroom contains Jones’s fingerprints. Jones was seen, by a neighbor, entering the Smith home at around 11:00 p.m. the night of Smith’s death. A coworker heard Smith and Jones arguing in Smith’s office the morning of the day Smith died.

Conclusion: Jones killed Smith.

Here, then, is the example in bullet form:

  • Conclusion: Jones killed Smith
  • Support: Smith was shot by Jones’ gun, Jones was seen entering the scene of the crime, Jones and Smith argued earlier in the day Smith died.
  • Assumption: The facts are representative, not isolated incidents, and thus reveal a trend, justifying the conclusion drawn.

When you use deduction in an argument, you begin with general premises and move to a specific conclusion. There is a precise pattern you must use when you reason deductively. This pattern is called syllogistic reasoning (the syllogism). Syllogistic reasoning (deduction) is organized in three steps:

  • Major premise
  • Minor premise

In order for the syllogism (deduction) to work, you must accept that the relationship of the two premises lead, logically, to the conclusion. Here are two examples of deduction or syllogistic reasoning:

  • Major premise: All men are mortal.
  • Minor premise: Socrates is a man.
  • Conclusion: Socrates is mortal.
  • Major premise: People who perform with courage and clear purpose in a crisis are great leaders.
  • Minor premise: Lincoln was a person who performed with courage and a clear purpose in a crisis.
  • Conclusion: Lincoln was a great leader.

So in order for deduction to work in the example involving Socrates, you must agree that (1) all men are mortal (they all die); and (2) Socrates is a man. If you disagree with either of these premises, the conclusion is invalid. The example using Socrates isn’t so difficult to validate. But when you move into more murky water (when you use terms such as courage , clear purpose , and great ), the connections get tenuous.

For example, some historians might argue that Lincoln didn’t really shine until a few years into the Civil War, after many Union losses to Southern leaders such as Robert E. Lee.

The following is a clear example of deduction gone awry:

  • Major premise: All dogs make good pets.
  • Minor premise: Doogle is a dog.
  • Conclusion: Doogle will make a good pet.

If you don’t agree that all dogs make good pets, then the conclusion that Doogle will make a good pet is invalid.

When a premise in a syllogism is missing, the syllogism becomes an enthymeme. Enthymemes can be very effective in argument, but they can also be unethical and lead to invalid conclusions. Authors often use enthymemes to persuade audiences. The following is an example of an enthymeme:

If you have a plasma TV, you are not poor.

The first part of the enthymeme (If you have a plasma TV) is the stated premise. The second part of the statement (you are not poor) is the conclusion. Therefore, the unstated premise is “Only rich people have plasma TVs.” The enthymeme above leads us to an invalid conclusion (people who own plasma TVs are not poor) because there are plenty of people who own plasma TVs who are poor. Let’s look at this enthymeme in a syllogistic structure:

  • Major premise: People who own plasma TVs are rich (unstated above).
  • Minor premise: You own a plasma TV.
  • Conclusion: You are not poor.

To help you understand how induction and deduction can work together to form a solid argument, you may want to look at the United States Declaration of Independence. The first section of the Declaration contains a series of syllogisms, while the middle section is an inductive list of examples. The final section brings the first and second sections together in a compelling conclusion.

https://media-cldnry.s-nbcnews.com/image/upload/rockcms/2024-09/240915-texas-medical-cadavers-main-vertical-edit-cs-a27760.jpg

Cut up and leased out, the bodies of the poor suffer a final indignity in Texas

The University of North Texas Health Science Center built a flourishing business using hundreds of unclaimed corpses. It suspended the program after NBC News exposed failures to treat the dead and their families with respect.

This article is part of “Dealing the Dead,” a series investigating the use of bodies for medical research.

DALLAS — Long before his bleak final years, when he struggled with mental illness and lived mostly on the streets, Victor Carl Honey joined the Army, serving honorably for nearly a decade. And so, when his heart gave out and he died alone 30 years later, he was entitled to a burial with military honors.

Instead, without his consent or his family’s knowledge, the Dallas County Medical Examiner’s Office gave his body to a state medical school, where it was frozen, cut into pieces and leased out across the country.

A Swedish medical device maker paid $341 for access to Honey’s severed right leg to train clinicians to harvest veins using its surgical tool. A medical education company spent $900 to send his torso to Pittsburgh so trainees could practice implanting a spine stimulator. And the U.S. Army paid $210 to use a pair of bones from his skull to educate military medical personnel at a hospital near San Antonio.

In the name of scientific advancement, clinical education and fiscal expediency, the bodies of the destitute in the Dallas-Fort Worth region have been routinely collected from hospital beds, nursing homes and homeless encampments and used for training or research without their consent — and often without the approval of any survivors, an NBC News investigation found.

Victor Honey at a shelter during a winter storm in Dallas.

Honey, who died in September 2022, is one of about 2,350 people whose unclaimed bodies have been given to the Fort Worth-based University of North Texas Health Science Center since 2019 under agreements with Dallas and Tarrant counties . Among these, more than 830 bodies were selected by the center for dissection and study. After the medical school and other groups were finished, the bodies were cremated and, in most cases, interred at area cemeteries or scattered at sea. Some had families who were looking for them.

For months as NBC News reported this article, Health Science Center officials defended their practices, arguing that using unclaimed bodies was essential for training future doctors. But on Friday, after reporters shared detailed findings of this investigation, the center announced it was immediately suspending its body donation program and firing the officials who led it. The center said it was also hiring a consulting firm to investigate the program’s operations.

“As a result of the information brought to light through your inquiries, it has become clear that failures existed in the management and oversight of The University of North Texas Health Science Center’s Willed Body Program,” the statement said. “The program has fallen short of the standards of respect, care and professionalism that we demand.”

Last year, NBC News revealed in its “Lost Rites” investigation that coroners and medical examiners in Mississippi and nationally had repeatedly failed to notify families of their loved ones’ deaths before burying them in pauper’s graveyards . That investigation led reporters to North Texas, where officials had come to view the unclaimed dead not as a costly burden, but as a free resource.

Before its sudden shuttering last week, the Health Science Center’s body business flourished. 

On paper, the arrangements with Dallas and Tarrant counties offered a pragmatic solution to an expensive problem: Local medical examiners and coroners nationwide bear the considerable costs of burying or cremating tens of thousands of unclaimed bodies each year. Disproportionately Black, male, mentally ill and homeless, these are individuals whose family members often cannot be easily reached, or whose relatives cannot or will not pay for cremation or burial.

The University of North Texas Health Science Center used some of these bodies to teach medical students. Others, like Honey’s, were parceled out to for-profit medical training and technology companies — including industry giants like Johnson & Johnson, Boston Scientific and Medtronic — that rely on human remains to develop products and teach doctors how to use them. The Health Science Center advertised the bodies as being of “the highest quality found anywhere in the U.S.”

Do you have a story to share about the use of unclaimed bodies for research? Contact us .

Proponents say using unclaimed bodies transforms a tragic situation into one of hope and service, providing a steady supply of human specimens needed to educate doctors and advance medical research. But for families who later discover their missing relatives were dissected and studied, the news is haunting, compounding their grief and depriving them of the opportunity to mourn.

“The county and the medical school are doing this because it saves them money, but that doesn’t make it right,” said Thomas Champney, an anatomy professor at the University of Miami Miller School of Medicine who researches the ethical use of human bodies . “Since these individuals did not consent, they should not be used in any form or fashion.”

The University of North Texas Health Center in Fort Worth.

A half-century ago, it was common for U.S. medical schools to use unclaimed bodies, and doing so remains legal in most of the country, including Texas. Many programs have halted the practice in recent years, though, and some states, including Hawaii, Minnesota and Vermont, have flatly prohibited it — part of an evolution of medical ethics that has called on anatomists to treat human specimens with the same dignity shown to living patients.

The University of North Texas Health Science Center charged in the opposite direction.

Through public records requests, NBC News obtained thousands of pages of government records and data documenting the acquisition, dissection and distribution of unclaimed bodies by the center over a five-year period.

An analysis of the material reveals repeated failures by death investigators in Dallas and Tarrant counties — and by the center — to contact family members who were reachable before declaring a body unclaimed. Reporters examined dozens of cases and identified 12 in which families learned weeks, months or years later that a relative had been provided to the medical school, leaving many survivors angry and traumatized.

Five of those families found out what happened from NBC News. Reporters used public records databases, ancestry websites and social media searches to locate and reach them within just a few days, even though county and center officials said they had been unable to find any survivors.

In one case, a man learned of his stepmother’s death and transfer to the center after a real estate agent called about selling her house. In another, Dallas County marked a man’s body as unclaimed and gave it to the Health Science Center, even as his loved ones filed a missing person report and actively searched for him.

From 2023: NBC News’ “Lost Rites” investigation

  • After a mother in Jackson, Mississippi, reported her son missing, police kept the truth from her for months.
  • ‘They just threw him away’: Another Mississippi man was buried without his family’s knowledge .
  • America’s patchwork death notification system routinely leaves families in the dark.
  • The Department of Justice took action after a Mississippi coroner buried men without notifying their families.
  • The Jackson Police Department adopted a next-of-kin notification policy following NBC News’ reporting.

Before the Health Science Center announced it was suspending the program, officials in the two counties had already told NBC News they were reconsidering their unclaimed body agreements in light of the reporters’ findings. 

Commissioners in Dallas County recently postponed a vote on whether to extend their contract. The top elected official in Tarrant County, Judge Tim O’Hare — who voted to renew the county’s agreement with the center in January — said he planned to explore legal options “to end any and all immoral, unethical, and irresponsible practices stemming from this program.”

“No individual’s remains should be used for medical research, nor sold for profit, without their pre-death consent, or the consent of their next of kin,” O’Hare’s office said . “The idea that families may be unaware that their loved ones’ remains are being used for research without consent is disturbing, to say the least.” 

NBC News also shared its findings with dozens of companies, teaching hospitals and medical schools that have relied on the Health Science Center to supply human specimens. Ten said they did not know the center had provided them with unclaimed bodies. Some, including Medtronic, said they had internal policies requiring consent from the deceased or their legal surrogate.

DePuy Synthes, a Johnson & Johnson company, said it had paused its relationship with the center after learning from a reporter that it had received body parts from four unclaimed people. And Boston Scientific, whose company Relievant Medsystems used the torsos of more than two dozen unclaimed bodies for training on a surgical tool , said it was reviewing its transactions with the center, adding that it had believed the program obtained consent from donors or families.

“We empathize with the families who were not reached as part of this process,” the company said.

The Army said it, too, was examining its reliance on the center and planned to review and clarify internal policies on the use of unclaimed bodies. Under federal contracts totaling about $345,000, the center has provided the Army with dozens of whole bodies, heads and skull bones since 2021 — including at least 21 unclaimed bodies. An Army spokesperson said officials had not considered the possibility that the program hadn’t gotten consent from donors or their families.

The Texas Funeral Service Commission, which regulates body donation programs in the state, is conducting a review of its own. In April, the agency issued a moratorium on out-of-state shipments while it studies a range of issues, including the use of unclaimed bodies by the Health Science Center.

In the case of Victor Honey, it shouldn’t have been hard for Dallas County investigators to find survivors: His son shares his father’s first and last name and lives in the Dallas area. Family members are outraged that no one from the county or the Health Science Center informed them of Honey’s death, much less sought permission to dissect his body and distribute it for training.

It wasn’t until a year and a half after he died that his relatives finally learned that news — from a chance encounter with a stranger struck by the similarity of the father’s and son’s names, followed by a phone call from NBC News.

“It’s like a hole in your soul that can never be filled,” said Brenda Cloud, one of Honey’s sisters. “We feel violated.”

Brenda Cloud

Two years before Honey’s death, Oscar Fitzgerald died of a drug overdose outside a Fort Worth convenience store. County officials failed to reach his siblings or adult children, so they had no voice in deciding whether to donate his body. It was taken to the University of North Texas Health Science Center, pumped with preservatives and assigned to a first-year medical student to study over the coming year.

Five months passed before his family learned from a friend in September 2020 that he was dead. ​​When his brother rushed to Fort Worth to claim the remains, he said he was told by the Health Science Center that he’d have to wait — the program was not done using the body.

Patrick Fitzgerald, who had last seen his 57-year-old brother the previous Thanksgiving, was aghast.

“Now that the family has come forward,” he said, “you mean to tell me we can’t have him?”

Instead, Fitzgerald said he was told his family must fill out donation consent forms to eventually receive his brother’s ashes. A year and a half later — after the body had been leased out a second time, to a Texas dental school — the center billed the family $54.50 in shipping costs for the box that arrived at Fitzgerald’s Arkansas home containing his brother’s remains. He also received a letter from Claudia Yellott, then the manager of UNT’s body donation program.

“UNT Health Science Center and our students value the selfless sacrifice made by your family,” Yellott wrote.

As of Friday, Yellott’s photo and bio were missing from the Health Science Center website, along with those of Rustin Reeves, the longtime director of the center’s anatomy program . Yellott confirmed to NBC News that she had been terminated and declined to comment further. Reeves did not respond to messages. The center declined to specify who was fired. 

The Fitzgeralds’ ordeal was the scenario one Tarrant County commissioner had feared in 2018, when Yellott and Reeves pitched their plan to receive the county’s unclaimed dead.

They described it as a win for everyone: The county would save on burial costs and the center would, as Yellott phrased it , obtain “valuable material” needed to educate future physicians.

The commissioners were elated at the prospect of saving up to a half-million dollars a year. But one, Andy Nguyen, questioned the morality of dissecting bodies of people with no family to consent and raised the possibility of survivors coming forward later, horrified to learn how their relatives were treated.

“Just because they don’t have any next of kin doesn’t mean they have no voice,” Nguyen said .

After the Health Science Center pledged to handle each body with dignity, all five commissioners voted to approve the agreement. A little over a year later, Dallas County struck a similar deal, with one major difference: While Tarrant County families who couldn’t afford to make funeral arrangements were given an option to donate their relatives’ bodies to the center, Dallas County gave survivors no choice.

Soon, a steady stream of bodies began to flow to the center. The program went from receiving 439 bodies in the 2019 fiscal year to nearly 1,400 in 2021 — about a third of them unclaimed dead from Dallas and Tarrant counties. This coincided with a multimillion-dollar expansion and renovation of the Health Science Center’s body storage facilities and laboratories.

The supply of unclaimed dead helped bring in about $2.5 million a year from outside groups, according to financial records . Many of those payments came from medical device makers that spent tens of thousands of dollars to use the center-run laboratory space, BioSkills of North Texas, to train clinicians on how to use their products — a revenue stream made possible by the school’s robust supply of “cadaveric specimens.”

That economic engine has now stalled; the center announced it was permanently closing the BioSkills lab in response to NBC News’ findings. In its statement, the center said it “is committed to addressing all issues and taking corrective actions to maintain public trust.”

The partnerships with Dallas and Tarrant counties, which drew little attention when they were adopted, quietly rippled through the community of professionals who work with the dead and dying in North Texas.

Eli Shupe, a bioethicist at the University of Texas at Arlington, was volunteering with a Tarrant County hospice provider in late 2021 when a chaplain made a comment that rocked her.

“Oh, poor Mr. Smith,” Shupe recalled the chaplain saying. “He doesn’t have long, and then it’s off to the medical school.”

Eli Shupe, a bioethicist professor at University of Texas at Arlington.

Her shock led Shupe to spend months studying the use of unclaimed bodies in Texas. As she investigated, she pondered a philosophical question: People have the right to make decisions about their bodies while they’re alive, but should that right die with them?

No, she ultimately concluded, it should not.

Shupe herself has signed up to give her body to the Health Science Center when she dies, in part to underscore that she doesn’t oppose body donation. But she emphasized that it was her choice.

“What they’re doing is uncomfortably close to grave-robbing,” she said.

Shupe was alluding to the dark history, long before voluntary body-donation programs, when U.S. medical schools turned to “resurrectionists,” or “body snatchers,” who dug up the graves of poor and formerly enslaved people. To curb this ghastly 19th-century practice, states adopted laws giving schools authority to use unclaimed bodies for student training and experiments.

Many of those laws remain on the books, but the medical community has largely moved beyond them. Last year, the American Association for Anatomy released guidelines for human body donation stating that “programs should not accept unclaimed or unidentified individuals into their programs as a matter of justice.”

Experts said the Health Science Center appeared to be an outlier in terms of the number of unclaimed bodies it used. No national data exists on this issue, so NBC News surveyed more than 50 major U.S. medical schools. Each of the 44 that answered said they don’t use unclaimed bodies — and some condemned doing so.

Joy Balta, an anatomist who runs a body donation program at Point Loma Nazarene University, chaired the committee that wrote the anatomy association’s new guidelines. He said using unclaimed bodies violates basic principles of dignity and consent now embraced by most experts in his field.

One reason that bodies should come only from consenting donors, Balta and others note: Some religions have strict views about how the dead should be treated.

“We don’t know if the individual is completely against their body being donated, and we can’t just disregard that,” Balta said.

Eli Shupe Teaches a class at University of Texas at Arlington.

Since 2021, dozens of entities have received unclaimed bodies from the Health Science Center — including some, like the University of Arkansas for Medical Sciences, that explicitly prohibit the practice on ethical grounds. 

The Little Rock-based school received shipments of skull bones and heads in 2023 and 2024 that included parts harvested from unclaimed bodies, records show. Leslie Taylor, a University of Arkansas medical school spokesperson, said because the UNT office that provided specimens is called the Willed Body Program , officials “believed they came from donors who willed their remains for education and study.”

Taylor said the school would adopt procedures to ensure it receives bodies only from people who have given explicit permission.

Before abruptly suspending the program last week, the Health Science Center had vigorously defended its practices. 

“An unclaimed individual is incapable of consenting to any process after death, which includes burial, donation, cremation, eco-burials or any other use of the body,” the center had said in a statement on Aug. 16. “If a relative is not located or does not claim the remains, a decision must still be made.”

Shupe argued that it’s problematic for a public medical school to benefit from the deaths of the “very poor” in its community. She has now embarked on a campaign to end the use of unclaimed bodies in Texas and nationally.

After publishing a newspaper essay criticizing the practice, she brought her concerns directly to the Tarrant County Commissioners Court at a meeting last year, asking officials to consider the message being sent to marginalized residents and people of color. 

“How does it look,” she said , “when a Black body is dissected with nobody’s permission at all, simply because they died poor?”

All Victor Honey’s family has to go by are faded memories, a handful of keepsakes, online snapshots and a trail of court records spanning eight states and Washington, D.C. These clues tell a disjointed story of an Army veteran tormented by paranoid delusions who repeatedly rejected help as he slid into homelessness and whose body went unclaimed, despite having a family who cared deeply for him.

His two sisters remember Honey teaching them math, making them laugh, shielding them from bullies and helping raise them when their parents divorced and moved the family from Mississippi to Cleveland in the 1970s. He was meticulous, hardworking, well-dressed — and in search of a calling.

After starting college, Honey joined the Army in late 1984 and reported to Texas’ Fort Hood, where he trained as a medic and, at a military club, danced with a soon-to-be Air Force enlistee named Kimberly. They married not long after and had a daughter. A son followed.

Photos of Victor Honey at 5 years old; at 16 years old with his younger brother; as an adult with his two young children.

The young family lived at the base until 1988, when Honey’s enlistment ended. He then joined the Army Reserves in Dallas and was called up to support the first Gulf War. Though he didn’t want to go, he spent four months in Germany, so upset about the deployment that he rarely left his base. He remained angry after he returned home.

Kimberly Patman said Honey had multiple affairs, leading them to separate in 1992, which threw him into a deep depression. He sought mental health services from a local Department of Veterans Affairs facility and was given antipsychotic medication that he quit after a month, saying he was allergic.

From there, his life unraveled.

In 1995, Honey was arrested in Dallas for trespassing. A doctor at the jail called Patman and said he’d had some kind of breakdown. She called his father in Cleveland, who brought him home.

He was diagnosed with paranoid schizophrenia but refused to take the medication that eased his delusional thoughts. He was convinced people were coming after him, barricaded himself in his room and became a compulsive hoarder, filing papers in a leather satchel.

He was off his medications in early 1997 when he stole a car from a dealership and robbed three banks in three states — each time handing a teller a note demanding money. He had no weapon. He was sentenced to three years in federal prison.

After he was released, Honey tried living in Cleveland, but abruptly left.

“He just disappeared,” Patman said. “They didn’t know where he was. We didn’t know where he was. And it was like that for years.”

He eventually drifted to Washington, where he wound up on the streets. He filed more than a dozen lawsuits, claiming an array of grievances. He posted a video to YouTube in which he showed his broken teeth and suggested the police were responsible. “This is a horrendous, horrendous life here in Washington,” he told the camera.

He landed in Dallas again in late 2018. He was arrested multiple times for fare evasion and filing a false police report, and appeared at city council meetings claiming he’d been wrongfully charged. He also pleaded guilty to assaulting an emergency room nurse who was attempting to provide him care.

And then came the phone call that brought the family together again.

Kimberly Patman, ex-wife of Victor C. Honey.

In early 2022, a caseworker at a Dallas-area hospital contacted Honey’s daughter, Victoria, in Montgomery, Alabama, to say he was in intensive care and might not survive, the family said. Patman and Victoria rushed to his side and were told his kidneys were failing.

“We’re here, the kids are here, we love you,” Patman told Honey. In response, he opened his eyes and asked, “Why did you divorce me?” They ended up laughing about it.

Brenda Cloud, his sister, called from Cleveland. “I would just talk to him and remind him of growing up and of his children, and he had a lot to fight for,” she said.

Honey’s condition improved, but he ignored advice to go to a nursing home and instead checked himself out. Several weeks later, he got on the phone with his namesake son. They’d often gone years without talking, but the son said he knew his father loved him.

That was Victor Carl Honey’s last contact with his family.

On Sept. 19, 2022, Honey was discovered semiconscious in a wheelchair at a downtown Dallas light rail station and taken to Baylor University Medical Center. He died early the next morning. He was 58.

The light rail station where Victor Honey's was found just before he died.

After a Baylor social worker was unable to find his family, Honey’s body was transported to the Dallas County Medical Examiner’s Office, where an investigator was assigned to find next of kin.

The county investigator sought information from police and area hospitals but was unable to locate relatives. She then turned to the internet, where she found numbers for Patman, Honey’s brother in Ohio, his stepmother and his late father, but she reported they were disconnected. On Oct. 17, 2022, the investigator wrote that her search was complete and no family was found. The medical examiner’s office deemed Honey’s body unclaimed.

That same day, Honey was delivered to the University of North Texas Health Science Center, where he was placed in a freezer, awaiting assignment.

One of the most solemn duties of local government is notifying families when someone dies. Though the world, in so many ways, has never been more connected, finding survivors still can be difficult in an era of growing homelessness and increasingly fractured families. 

Death investigators at the Dallas County Medical Examiner’s Office follow a detailed checklist: They reach out to area hospitals to seek emergency contact information, search missing person reports, and comb public records databases for possible phone numbers. They also call neighbors and homeless shelters. If no family is found, they must sign an affidavit stating they did all they could.

In Tarrant County, officials delegated the primary responsibility for contacting next of kin to the Health Science Center, which said it takes similar steps.

But these efforts repeatedly fell short.

For two and a half years, Fran Moore of Lodi, New York, didn’t know what happened to her 79-year-old father, Carl Yenner. She cried when an NBC News reporter notified her in February that he had died at a Dallas hospital in May 2021 and his body had been sent to the Health Science Center.

Carl Yenner

Moore said she and her brother had struggled to stay in touch with their father across the miles. After not hearing from him, her brother filed a missing person report in Wichita Falls, about two hours from Dallas, where Yenner had lived. They still don’t know how he wound up in Dallas, how he died or why nobody contacted them. A Dallas County worker signed a form in June 2021 stating she had completed an exhaustive search for possible relatives.

But after spotting Yenner’s name on a list of unclaimed bodies provided by Dallas County, NBC News quickly identified Moore and her brother as Yenner’s children and found working phone numbers for each of them.

“If you could find us,” Moore said, “why didn’t they?”

Another question left unanswered: Given that Yenner was an Army veteran and entitled to federal burial benefits , what was the economic argument for Dallas County to send his body to the Health Science Center? At least 32 unclaimed veterans, including Honey, have been given to the program since 2020, records show.

After the center was done with Yenner’s body, it was cremated and interred among fellow service members at Dallas-Fort Worth National Cemetery. Moore said she’s heartbroken she couldn’t bury him with the rest of his family in New Jersey.

“To not have any kind of funeral for him,” she said, “for his family to come see him to say goodbye?”

Without commenting on specific cases, Dallas County Administrator Darryl Martin offered condolences to families whose relatives were used by the program. He said his staff works hard to locate family members and treats bodies with dignity. He didn’t address the use of unclaimed veterans.

In January, in an attempt to improve its efforts to find survivors in Tarrant County, the Health Science Center hired a company called The Voice After Life , whose mission is to help governments locate families of the unclaimed. The center said it has found families in about 80% of cases since then; officials did not know the previous success rate.

In a statement issued weeks before announcing it was suspending the program, the center said it “seeks to understand and honor the wishes of the family and deceased.”

It did not, however, honor the wishes of Michael Dewayne Coleman’s relatives. 

Coleman, 43, died alone on Oct. 21, 2023, in a Dallas hospital after possibly being hit by a car. An investigator for the medical examiner signed off on his case file, saying “all reasonable efforts” had been made to find next of kin.

But his relatives should have been easy to reach. More than a week before his death, his fiancée, Louisa Harvey, had filed a missing person report with the Dallas Police Department after he failed to return from a night out with friends, not knowing he was already languishing in a hospital. She spent months searching for him, alongside two of Coleman’s sisters. She printed missing person posters and canvassed neighborhoods near their home.

Michael DeWayne Coleman and his fiance.

She said she called the detective assigned to the missing person case almost every day, eventually suspecting that finding Coleman wasn’t a priority because of his criminal record, which included illegal drug use and two domestic violence convictions.

Harvey finally learned of his death in March, after the Dallas County medical examiner listed him as an unclaimed body in the National Missing and Unidentified Persons System, or NamUs , a free federal database meant to connect missing person reports with reports of unclaimed bodies. By the time Harvey found the posting online, the medical examiner had sent Coleman’s body to the Health Science Center.

His family could have learned of his death months earlier if the police detective assigned to find Coleman had listed him as a missing person in NamUs, but records show he never did. In response to questions from NBC News, a Dallas Police spokesperson said the department had opened an internal investigation into the detective’s handling of the case and would implement a policy change to prevent similar mistakes. 

Harvey couldn’t believe Coleman’s body had been donated without the family’s consent — or his. Last year, while filling out an application for a state ID, she said, Coleman had made clear he didn’t want his organs donated because of his distrust of the medical system; she doubts he would have wanted to donate his whole body.

But when Harvey and one of Coleman’s sisters, Shea Coleman, repeatedly asked the medical examiner and the Health Science Center to release his body — or at least to let them view it — they were told no. In June, a worker at the medical examiner’s office wrote in case notes that she spoke to Yellott, the manager of UNT’s body donation program, who told her Coleman was slated to be used in a longer-term course and that his family could receive his remains when the center was finished with him.

In 12 to 24 months.

In August, after NBC News inquired about his case, a Health Science Center official told reporters that Coleman’s body would be cremated and returned to the family much sooner — an abrupt reversal that the center attributed to the Texas Funeral Service Commission’s temporary ban on out-of-state body shipments. Ten days later, the medical examiner called Harvey to let her know Coleman’s ashes were ready to be picked up.

The center’s refusal to let her see her fiancé’s body has made it harder to grieve, Harvey said.

“I’m lying awake every night thinking, ‘Is that my Michael?’” she said. “‘Did he actually die?’”

After Victor Honey’s body arrived at the University of North Texas Health Science Center, the harvesting began.

Depending on how they were to be used, bodies were either frozen or embalmed. Some were left whole and set aside to train students. Others, like Honey’s , were dissected with scalpels and bone saws, to be distributed on the open market.

In November 2022, Honey’s right leg was used in a training at the center paid for by Getinge, a Swedish medical technology company that makes instruments for use in a surgical procedure called endoscopic vein harvest.

In January 2023, a week after the medical examiner’s office reported that Honey was eligible for a veteran’s burial, bones from his skull were shipped to Brooke Army Medical Center at Fort Sam Houston — where Honey had been ordered to report before his Gulf War deployment more than three decades earlier.

In May 2023, the Health Science Center shipped Honey’s torso to Pittsburgh, where the training company National Bioskills Laboratories provided it to a medical product company renting its facilities to teach doctors a pain-relief procedure called spinal cord stimulation.

NBC News informed Getinge, the Army and National Bioskills about the center’s regular use of unclaimed bodies and Honey’s family not providing consent.

Dr. Douglas Hampers, National Bioskills’ CEO and an orthopedic surgeon, said he was disturbed to learn his company has received unclaimed bodies and expressed sympathy for Honey’s family.

While human specimens are crucial for medical advances, Hampers said bodies should not be used without consent. He said his company would ensure that it no longer accepted unclaimed bodies and would adopt policies to make certain future specimens were donated with families’ permission.

“I don’t think you have to violate a family’s rights in order to train physicians,” he said.

A Getinge spokesperson emailed a statement saying only that the company regularly reviews its policies and operations, “including what we expect from our suppliers.”

In a statement, the Army said that if Honey’s remains were procured legally, the use of his body complied with the service’s current policies.

In July 2023, after Honey’s torso had been returned to the Health Science Center, his remains were cremated and later his ashes were brought to the Dallas County medical examiner.

And there they sat, with no one to claim them. Months passed.

Victor Honey, son of Victor C. Honey

In late April, Honey’s son, Victor, was boxing cans at the Dallas food bank where he volunteered when a woman approached him. She’d overheard someone calling out his name. “Do you know someone else named Victor Honey?” she asked him.

The woman said she knew his father when they both stayed at a downtown homeless shelter and had heard he died. Victor didn’t want to believe it. He tried to put it out of his mind. But the next morning, he called his mother and told her what he’d heard. She cried out and burst into tears.

An internet search led Victor to the medical examiner’s office, which confirmed the details of his father’s death and later told him the remains were available to be picked up.

About the same time, NBC News had found Honey’s name on a list of people whose unclaimed bodies were obtained by the Health Science Center. Using public records, a reporter tracked down Patman, Honey’s ex-wife, and sent her a message on Facebook. She responded immediately.

On a call, the reporter broke the news of how Honey’s body was used.

His family was appalled. Patman said she would have argued against Honey being cut apart and studied, noting that he once told her that he didn’t want to be an organ donor. Victor, though, said he might have been open to donating his father’s body for medical research.

“But y’all should have asked us about it,” he said. “They just sent his body parts away.”

A uniformed military officer presents the American flag to a relative of Victor Honey at his burial.

When the family gathered in early June to finally lay Honey to rest, many expressed remorse about not being able to help him. They were frustrated to have no say in what happened to his body. And they said they hoped sharing his story would help spare others from similar anguish.

“Victor had a big, strong family,” Patman told family members. “And now we are going to speak for him.”

On a muggy Monday morning, a couple dozen of Honey’s relatives — nieces and nephews, siblings and cousins, Patman and their children — gathered in a pavilion at the Dallas-Fort Worth National Cemetery for the farewell they had long been denied.

A recording of taps played. A soldier knelt in front of Honey’s daughter, Victoria, and handed her a folded U.S. flag “as a symbol of our appreciation of your loved one’s honorable and faithful service.”

After the funeral, Honey’s relatives made their way to Section 40, Grave No. 464, where a crew dug a hole and placed the urn in the ground. They installed a temporary marker that soon would be replaced by a white granite headstone standing among rows of thousands.

Brenda Cloud, Honey’s sister, is furious over what transpired in the 622 days between her brother’s death and his burial. And she wants answers for the others whose bodies were cut up and studied without consent.

“Whether they had family or not,” she said, “every person deserves to have that dignity.”

Victor Honey had a family who cared about him — and now they plan to speak for him.

Mike Hixenbaugh is a senior investigative reporter for NBC News, based in Maryland, and author of "They Came for the Schools."

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Jon Schuppe is an enterprise reporter for NBC News, based in New York.

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Susan Carroll was a senior enterprise editor for NBC News, based in Houston.

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Psychedelic drug psilocybin may rewire brain connectivity to treat body dysmorphic disorder, research suggests

by Genomic Press

Psychedelic drug psilocybin changes brain connectivity to treat body dysmorphic disorder

Body dysmorphic disorder (BDD) is a debilitating mental illness characterized by an obsessive preoccupation with perceived flaws in one's physical appearance. Patients with BDD often have distorted self-image, intrusive thoughts, and compulsive behaviors that significantly impair daily functioning and quality of life. Current therapies have limited efficacy, leaving many sufferers without relief.

A study led by researchers at Columbia University and published in Psychedelics provides hope by revealing how the psychedelic drug psilocybin , the active ingredient in "magic mushrooms," may rewire connectivity of brain circuitry, potentially aiding in the treatment of this debilitating disorder. The paper is titled "Single-Dose Psilocybin Alters Resting State Functional Networks in Patients with Body Dysmorphic Disorder."

In the pilot trial, eight adults with moderate-to-severe BDD that had not responded to standard treatments received a single 25mg oral dose of psilocybin in a supportive setting. Using cutting-edge functional MRI technology, the scientists scanned the participants' brains one day before and one day after the psilocybin session. Sophisticated pattern analysis techniques were then applied to map changes in brain network connectivity and link them to subsequent clinical outcomes.

The results were striking: Just one day after psilocybin administration, the patients exhibited increased connectivity both within a network governing executive functions , and between this network and others involved in processing emotionally salient stimuli and self-referential thinking. Notably, those who showed the greatest strengthening of these neural connections also experienced the most improvement in BDD symptoms one week later.

While preliminary, the findings align with a growing body of evidence indicating that psychedelic compounds like psilocybin can promote mental health by enhancing the brain's capacity for flexibility and integration. By facilitating communication within and between brain networks that are often dysregulated in psychiatric disorders , psilocybin may help restore more adaptive cognitive and emotional functioning.

As the first study of psilocybin in a BDD population, the trial was small and lacked a placebo control. The researchers caution that larger, placebo-controlled studies are needed to verify the efficacy and durability of the treatment. Still, the robust brain-behavior relationships uncovered bode well for the ongoing development of psilocybin therapy.

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Research quantifying “nociception” could help improve management of surgical pain

New statistical models based on rigorous physiological data from more than 100 surgeries provide objective, accurate measures of “nociception,” the body’s subconscious perception of pain.

The degree to which a surgical patient’s subconscious processing of pain, or “nociception,” is properly managed by their anesthesiologist will directly affect the degree of post-operative drug side effects they’ll experience and the need for further pain management they’ll require. But pain is a subjective feeling to measure, even when patients are awake, much less when they are unconscious. In a new study, MIT and Massachusetts General Hospital (MGH) researchers describe a set of statistical models that objectively quantified nociception during surgery. Ultimately, they hope to help anesthesiologists optimize drug dose and minimize post-operative pain and side effects.

The new models integrate data meticulously logged over 18,582 minutes of 101 abdominal surgeries in men and women at MGH. Led by former MIT graduate student Sandya Subramanian , now an assistant professor at UC Berkeley and UC San Francisco, the researchers collected and analyzed data from five physiological sensors as patients experienced a total of 49,878 distinct “nociceptive stimuli” (such as incisions or cautery). Moreover, the team recorded what drugs were administered, and how much and when, to factor in their effects on nociception or cardiovascular measures. They then used all the data to develop a set of statistical models that performed well in retrospectively indicating the body’s response to nociceptive stimuli.

The team’s goal is to furnish such accurate, objective, and physiologically principled information in real-time to anesthesiologists who currently have to rely heavily on intuition and past experience in deciding how to administer pain-control drugs during surgery. If anesthesiologists give too much, patients can experience side effects ranging from nausea to delirium. If they give too little, patients may feel excessive pain after they awaken.

“Sandya’s work has helped us establish a principled way to understand and measure nociception (unconscious pain) during general anesthesia,” said study senior author Emery N. Brown , Edward Hood Taplin Professor of Medical Engineering and Computational Neuroscience in The Picower Institute for Learning and Memory, the Institute for Medical Engineering and Science, and the Department of Brain and Cognitive Sciences at MIT. Brown is also an anesthesiologist at MGH and a Professor at Harvard Medical School. “Our next objective is to make the insights that we have gained from Sandya’s studies reliable and practical for anesthesiologists to use during surgery.”

Surgery and statistics

The research, publsihed in the Proceedings of the National Academy of Sciences , began as Subramanian’s doctoral thesis project in Brown’s lab in 2017.  The best prior attempts to objectively model nociception have either relied solely on the electrocardiogram (ECG, an indirect indicator of heart-rate variability) or other systems that may incorporate more than one measurement, but were either based on lab experiments using pain stimuli that do not compare in intensity to surgical pain or were validated by statistically aggregating just a few time points across multiple patients’ surgeries, Subramanian said.

“There’s no other place to study surgical pain except for the operating room,” Subramanian said. “We wanted to not only develop the algorithms using data from surgery, but also actually validate it in the context in which we want someone to use it. If we are asking them to track moment-to-moment nociception during an individual surgery, we need to validate it in that same way.”

So she and Brown worked to advance the state of the art by collecting multi-sensor data during the whole course of actual surgeries and by accounting for the confounding effects of the drugs administered. In that way, they hoped to develop a model that could make accurate predictions that remained valid for the same patient all the way through their operation.

Part of the improvements the team achieved arose from tracking patterns of heart rate and also skin conductance. Changes in both of these physiological factors can be indications of the body’s primal “fight or flight” response to nociception or pain, but some drugs used during surgery directly affect cardiovascular state , while skin conductance (or “EDA,” electrodermal activity) remains unaffected. The study measures not only ECG but also backs it up with PPG, an optical measure of heart rate (like the oxygen sensor on a smartwatch), because ECG signals can sometimes be made noisy by all the electrical equipment buzzing away in the operating room. Similarly, Subramanian backstopped EDA measures with measures of skin temperature to ensure that changes in skin conductance from sweat were because of nociception and not simply the patient being too warm. The study also tracked respiration.

Then the authors performed statistical analyses to develop physiologically relevant indices from each of the cardiovascular and skin conductance signals. And once each index was established, further statistical analysis enabled tracking the indices together to produce models that could make accurate, principled predictions of when nociception was occurring and the body’s response.

Nailing nociception

In four versions of the model, Subramanian “supervised” them by feeding them information on when actual nociceptive stimuli occurred so that they could then learn the association between the physiological measurements and the incidence of pain-inducing events. In some of these trained versions she left out drug information and in some versions she used different statistical approaches (either “linear regression” or “random forest”). In a fifth version of the model, based on a “state space” approach, she left it unsupervised, meaning it had to learn to infer moments of nociception purely from the physiological indices. She compared all five versions of her model to one of the current industry standards, an ECG-tracking model called ANI.

Each model’s output can be visualized as a graph plotting the predicted degree of nociception over time. ANI performs just above chance but is implemented in real time. The unsupervised model performed better than ANI, though not quite as well as the supervised models. The best performing of those was one that incorporated drug information and used a “random forest” approach. Still, the authors note, the fact that the unsupervised model performed significantly better than chance suggests that there is indeed an objectively detectable signature of the body’s nociceptive state even when looking across different patients.

“A state space framework using multisensory physiological observations is effective in uncovering this implicit nociceptive state with a consistent definition across multiple subjects,” wrote Subramanian, Brown and their co-authors. “This is an important step toward defining a metric to track nociception without including nociceptive ‘ground truth’ information, most practical for scalability and implementation in clinical settings.”

Indeed the next steps for the research are to increase the data sampling and to further refine the models so that they can eventually be put into practice in the operating room. That will require enabling them to predict nociception in real-time, rather than in post-hoc analysis. When that advance is made, that will enable anesthesiologists or intensivists to inform their pain drug dosing judgements. Further into the future, the model could inform closed-loop systems that automatically dose drugs under the anesthesiologist’s supervision.

“Our study in an important first step toward developing objective markers to track surgical nociception,” the authors concluded. “These markers will enable objective assessment of nociception in other complex clinical settings, such as the ICU, as well as catalyze future development of closed-loop control systems for nociception.”

In addition to Subramanian and Brown, the paper’s other authors are Bryan Tseng, Marcela del Carmen, Annekathryn Goodman, Douglas Dahl and Riccardo Barbieri.

Funding from The JPB Foundation, The Picower Institute for Learning and Memory, George J. Elbaum (MIT '59, SM '63, PhD '67), Mimi Jensen, Diane B. Greene (MIT, SM '78), Mendel Rosenblum, Bill Swanson, Cathy and Lou Paglia, annual donors to the Anesthesia Initiative Fund , the National Science Foundation and an MIT Office of Graduate Education Collabmore-Rogers Fellowship supported the research.

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Understanding the Body’s Universe of Atoms

IRP’s Adriaan Bax Elected to Royal Society for Pioneering Nuclear Magnetic Resonance Methods

By Melissa Glim

Wednesday, September 18, 2024

Dr. Adrian Baax

IRP Distinguished Investigator Adriaan Bax was elected a Fellow of the Royal Society earlier this year for his contributions to a scientific technique that sheds light on the structure and function of molecules.

“My mortal body is indeed a universe of atoms, but I am just an atom in the universe myself,” physicist Richard Feynman once wrote in a poem. Within our own bodily universes, all those atoms tell a story about how our bodies work — and how they sometimes don’t.

IRP Distinguished Investigator  Adriaan Bax, Ph.D. , has pioneered ways to watch those atoms using nuclear magnetic resonance (NMR) methods. This year, he was elected a Fellow of the Royal Society in recognition of his research, which has contributed greatly to our knowledge of how the proteins and nucleic acids that keep our bodies running smoothly are structured, how they move, and how they interact, particularly in relation to diseases caused by their malformations and malfunctions. The Royal Society, which was founded in England in the 1660s, is a fellowship of many of the world’s most eminent scientists and is the oldest scientific academy in continuous existence. 

“It is, of course, very exciting for me to receive this exceptional honor,” Dr. Bax says. “I am particularly pleased because I still feel a strong connection with Great Britain, where I received much of my graduate student training and where I became really excited about pursuing a career in research.” 

Every molecule in existence is made up of individual atoms of the various elements in the periodic table, so marking and tracking atoms within molecules can yield important insights into their structure and movement. Dr. Bax’s specialty, NMR spectroscopy, measures very weak radiofrequency signals emitted by certain atoms when they’re placed in a strong magnetic field. Dr. Bax specifically focuses on creating ways to link each radiofrequency signal to a specific atom in the molecule, which allows for a more extensive and in-depth analysis and visualization of molecules — a vital topic of study given that those molecules can make the difference between a healthy and unhealthy body.

NMR spectrometer

An NMR spectrometer

“My work has focused on improving the technology to make it more sensitive and to allow us to study more complex systems,” Dr. Bax says. “There is much practical interest in our work, both for pharmaceutical applications to develop new medicines and for basic research to gain deeper insights into how proteins move and interact with one another.”

Most people have heard of magnetic resonance imaging (MRI), which detects signals from the hydrogen atoms in the body's water molecules and uses them to create a map of organs, empty spaces, and abnormalities. NMR spectroscopy is conceptually similar to MRI, except that it focuses on small samples of specific molecules, including proteins, and detects signals from a range of atoms, such as hydrogen, carbon, nitrogen, and phosphorus. The way those atoms are arranged in a molecule determines its shape, and that shape, in turn, determines its function. Proteins can also adjust their shape to better interact with partners or in response to binding with a drug. Problems can occur when proteins fold into abnormal shapes, causing them to stick together in specific ways. Diseases like Alzheimer’s and Parkinson’s, which are characterized by a buildup of amyloid plaques and hardened bits of other proteins, are examples of the types of ‘protein-misfolding’ diseases that Dr. Bax studies using NMR spectroscopy. 

“At their very basic level, many diseases occur when interactions between proteins and other molecules in our bodies fail to function properly,” Dr. Bax explains. “Many diseases are related to a misfunctioning protein pathway.”

While NMR has a long history of delivering significant improvements on researchers’ abilities to visualize proteins, Dr. Bax’s primary contribution, triple resonance NMR, has expanded the scope of biological NMR considerably. In addition to the traditionally studied hydrogen atoms, his triple resonance NMR relies on carbon and nitrogen atoms containing an atypical number of neutrons in their nucleus, known as isotopes. 

Dr. Bax’s team genetically modifies cells to make the proteins the group wants to study and feeds them a mixture containing high levels of those naturally occurring isotopes. The cells then incorporate the isotopes into the proteins they generate, initially as a linear string of chemically bonded building blocks called amino acids. The isotopes emit weak radiofrequency signals when exposed to the magnetic field in an NMR spectroscopy machine, allowing for their location in the protein to be mapped and followed as the linear, flexible string folds into a well-defined but partially flexible three-dimensional structure.

structural diagram of a protein

NMR can reveal detailed information about the shape of proteins, which determines how they function.

“Proteins are not rigid Lego blocks; they have built-in flexibility, and that flexibility is important for their function,” Dr. Bax explains. “We can measure this flexibility in great detail with NMR spectroscopy using signals from nitrogen isotopes.” For example, his team has demonstrated that a protein called calmodulin, found in the ‘smooth’ muscle that makes up many of our internal organs, binds to well over a hundred different targets, and it can do this, Dr. Bax adds, “because it has two sections, each of which behaves like a human hand, with the two of them tightly clasping onto their target from opposite sides.” 1,2

“When we first tried to publish our development of triple resonance NMR, it was rejected by scientific journals with the argument that it was ‘technologically interesting, but we don’t need this kind of complicated technology,’” Dr. Bax recalls. “Now, it is the method of choice world-wide for studying proteins and their motions.”

Another important advancement Dr. Bax’s team made involves finding ways to ‘weakly orient’ proteins in a magnetic field. Molecules scientists want to study with NMR spectroscopy can be coached to all point in the same direction, like soldiers ready to march, by dissolving them in a liquid crystalline solvent, similar to the substance used in digital watch displays, then exposing them to a magnetic field. However, with large molecules, this uniformity causes NMR signals to become broad, fuzzy, and overly complex, making it impossible to see the signals clearly. 

Dr. Adriaan Bax working with equipment in his lab

Creating new ways to study molecules with NMR sometimes means getting hands-on with the machines that perform it.

It’s a problem Dr. Bax had been working to correct since his undergraduate days in The Netherlands, and he finally solved it in 1997 using insights from a lecture on chemical techniques used in the petrochemical industry. The resulting approach, which uses a different substance to dissolve molecules, yields exceptionally clean information about the orientation of chemical bonds in a protein or a nucleic acid. This approach allows researchers to get a more accurate picture of molecular structure and increases the size of the molecules they can look at. The discovery, published in the prestigious journal Science , has become the cornerstone of numerous subsequent studies. 3,4  

“This very precise information allows us to learn something about molecules’ motions, too,” Dr. Bax explains. “So, for example, if a drug binds on one side of the protein, does that impact the opposite side of the protein where, for example, a site that binds to other molecules might be located? That is really a gold mine of information because it yields insights into how signals can be transmitted in the body.” 

Dr. Bax emphasizes that working at NIH has allowed him the freedom to pursue a lot of out-of-the-box ideas that had a high risk of failure. As a result, he has managed to make important discoveries that sometimes defy the expectations of his fellow scientists.

“I've got about 20 scientific papers that have been cited over a thousand times each, and nearly half of those were originally rejected for publication by peer reviewers,” he says. “The ones with the most impact were the hardest to get published.”

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References:

[1] Ikura M; Kay LE; Bax A.  A novel approach for sequential assignment of 1H, 13C, and 15N spectra of proteins: heteronuclear triple-resonance three-dimensional NMR spectroscopy. Application to calmodulin. Biochemistry . 1990 Oct. 1; 29 (19): 4659–67. doi:10.1021/bi00471a022.

[2] Kay LE, Ikura M, Tschudin R, Bax A.  Three-dimensional triple-resonance NMR spectroscopy of isotopically enriched proteins . J Magn. Reson . 1990 Oct. 1; 89 (3): 496–514. doi: 10.1016/0022-2364(90)90333-5.

[3] Tjandra N, Bax A.  Direct measurement of distances and angles in biomolecules by NMR in a dilute liquid crystalline medium . Science . 1997 Nov. 7; 278(5340):1111-1114. doi: 10.1126/science.279.5340.1111.

[4] Bax A.  Weak alignment offers new NMR opportunities to study protein structure and dynamics . Protein Sci. 2003; 12(1):1-16. doi: 10.1110/ps.0233303.

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Methodology

Research Methods | Definitions, Types, Examples

Research methods are specific procedures for collecting and analyzing data. Developing your research methods is an integral part of your research design . When planning your methods, there are two key decisions you will make.

First, decide how you will collect data . Your methods depend on what type of data you need to answer your research question :

  • Qualitative vs. quantitative : Will your data take the form of words or numbers?
  • Primary vs. secondary : Will you collect original data yourself, or will you use data that has already been collected by someone else?
  • Descriptive vs. experimental : Will you take measurements of something as it is, or will you perform an experiment?

Second, decide how you will analyze the data .

  • For quantitative data, you can use statistical analysis methods to test relationships between variables.
  • For qualitative data, you can use methods such as thematic analysis to interpret patterns and meanings in the data.

Table of contents

Methods for collecting data, examples of data collection methods, methods for analyzing data, examples of data analysis methods, other interesting articles, frequently asked questions about research methods.

Data is the information that you collect for the purposes of answering your research question . The type of data you need depends on the aims of your research.

Qualitative vs. quantitative data

Your choice of qualitative or quantitative data collection depends on the type of knowledge you want to develop.

For questions about ideas, experiences and meanings, or to study something that can’t be described numerically, collect qualitative data .

If you want to develop a more mechanistic understanding of a topic, or your research involves hypothesis testing , collect quantitative data .

Qualitative to broader populations. .
Quantitative .

You can also take a mixed methods approach , where you use both qualitative and quantitative research methods.

Primary vs. secondary research

Primary research is any original data that you collect yourself for the purposes of answering your research question (e.g. through surveys , observations and experiments ). Secondary research is data that has already been collected by other researchers (e.g. in a government census or previous scientific studies).

If you are exploring a novel research question, you’ll probably need to collect primary data . But if you want to synthesize existing knowledge, analyze historical trends, or identify patterns on a large scale, secondary data might be a better choice.

Primary . methods.
Secondary

Descriptive vs. experimental data

In descriptive research , you collect data about your study subject without intervening. The validity of your research will depend on your sampling method .

In experimental research , you systematically intervene in a process and measure the outcome. The validity of your research will depend on your experimental design .

To conduct an experiment, you need to be able to vary your independent variable , precisely measure your dependent variable, and control for confounding variables . If it’s practically and ethically possible, this method is the best choice for answering questions about cause and effect.

Descriptive . .
Experimental

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Research methods for collecting data
Research method Primary or secondary? Qualitative or quantitative? When to use
Primary Quantitative To test cause-and-effect relationships.
Primary Quantitative To understand general characteristics of a population.
Interview/focus group Primary Qualitative To gain more in-depth understanding of a topic.
Observation Primary Either To understand how something occurs in its natural setting.
Secondary Either To situate your research in an existing body of work, or to evaluate trends within a research topic.
Either Either To gain an in-depth understanding of a specific group or context, or when you don’t have the resources for a large study.

Your data analysis methods will depend on the type of data you collect and how you prepare it for analysis.

Data can often be analyzed both quantitatively and qualitatively. For example, survey responses could be analyzed qualitatively by studying the meanings of responses or quantitatively by studying the frequencies of responses.

Qualitative analysis methods

Qualitative analysis is used to understand words, ideas, and experiences. You can use it to interpret data that was collected:

  • From open-ended surveys and interviews , literature reviews , case studies , ethnographies , and other sources that use text rather than numbers.
  • Using non-probability sampling methods .

Qualitative analysis tends to be quite flexible and relies on the researcher’s judgement, so you have to reflect carefully on your choices and assumptions and be careful to avoid research bias .

Quantitative analysis methods

Quantitative analysis uses numbers and statistics to understand frequencies, averages and correlations (in descriptive studies) or cause-and-effect relationships (in experiments).

You can use quantitative analysis to interpret data that was collected either:

  • During an experiment .
  • Using probability sampling methods .

Because the data is collected and analyzed in a statistically valid way, the results of quantitative analysis can be easily standardized and shared among researchers.

Research methods for analyzing data
Research method Qualitative or quantitative? When to use
Quantitative To analyze data collected in a statistically valid manner (e.g. from experiments, surveys, and observations).
Meta-analysis Quantitative To statistically analyze the results of a large collection of studies.

Can only be applied to studies that collected data in a statistically valid manner.

Qualitative To analyze data collected from interviews, , or textual sources.

To understand general themes in the data and how they are communicated.

Either To analyze large volumes of textual or visual data collected from surveys, literature reviews, or other sources.

Can be quantitative (i.e. frequencies of words) or qualitative (i.e. meanings of words).

If you want to know more about statistics , methodology , or research bias , make sure to check out some of our other articles with explanations and examples.

  • Chi square test of independence
  • Statistical power
  • Descriptive statistics
  • Degrees of freedom
  • Pearson correlation
  • Null hypothesis
  • Double-blind study
  • Case-control study
  • Research ethics
  • Data collection
  • Hypothesis testing
  • Structured interviews

Research bias

  • Hawthorne effect
  • Unconscious bias
  • Recall bias
  • Halo effect
  • Self-serving bias
  • Information bias

Quantitative research deals with numbers and statistics, while qualitative research deals with words and meanings.

Quantitative methods allow you to systematically measure variables and test hypotheses . Qualitative methods allow you to explore concepts and experiences in more detail.

In mixed methods research , you use both qualitative and quantitative data collection and analysis methods to answer your research question .

A sample is a subset of individuals from a larger population . Sampling means selecting the group that you will actually collect data from in your research. For example, if you are researching the opinions of students in your university, you could survey a sample of 100 students.

In statistics, sampling allows you to test a hypothesis about the characteristics of a population.

The research methods you use depend on the type of data you need to answer your research question .

  • If you want to measure something or test a hypothesis , use quantitative methods . If you want to explore ideas, thoughts and meanings, use qualitative methods .
  • If you want to analyze a large amount of readily-available data, use secondary data. If you want data specific to your purposes with control over how it is generated, collect primary data.
  • If you want to establish cause-and-effect relationships between variables , use experimental methods. If you want to understand the characteristics of a research subject, use descriptive methods.

Methodology refers to the overarching strategy and rationale of your research project . It involves studying the methods used in your field and the theories or principles behind them, in order to develop an approach that matches your objectives.

Methods are the specific tools and procedures you use to collect and analyze data (for example, experiments, surveys , and statistical tests ).

In shorter scientific papers, where the aim is to report the findings of a specific study, you might simply describe what you did in a methods section .

In a longer or more complex research project, such as a thesis or dissertation , you will probably include a methodology section , where you explain your approach to answering the research questions and cite relevant sources to support your choice of methods.

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Redirect Notice

Inclusion of women and minorities as participants in research involving human subjects.

Learn about the policy for the Inclusion of Women and Minorities in NIH-funded research and how to comply with this policy in applications and progress reports.

NIH is mandated by the Public Health Service Act sec. 492B, 42 U.S.C. sec. 289a-2 to ensure the inclusion of women and members of racial and ethnic minority groups in all NIH-funded clinical research in a manner that is appropriate to the scientific question under study. The primary goal of this law is to ensure that research findings can be generalizable to the entire population. Additionally, the statute requires clinical trials to be designed to analyze whether study outcomes differ for women and members of racial and ethnic minority groups.

Implementation

Applications & proposals.

All NIH-funded studies that meet the NIH definition for clinical research must address plans for the inclusion of women and minorities within the application or proposal. Using the PHS Human Subjects and Clinical Trial Information Form, applications and proposals should describe the composition of the proposed study population in terms of sex or gender, racial, and ethnic groups, and provide a rationale for the proposed section. Any exclusions based on sex or gender, race, or ethnicity must include a rationale and justification based on a scientific or ethical basis. Investigators should also plan for appropriate outreach programs and activities to recruit and retain the proposed study population consistent with the purposes of the research project. Refer to the PHS Human Subjects and Clinical Trial Information Form Instructions for complete guidance on what to address in your application.

Peer Review

Scientific Review Groups will assess each application/proposal as being "acceptable" or "unacceptable" with regard to the inclusion of racial and ethnic minorities and women in the research project. For additional information on review considerations, refer to the Guidelines for the Review of Inclusion in Clinical Research . For information regarding the coding used to rate inclusion during peer review, see the list of NIH Peer Review Inclusion Codes .

Progress Reports

NIH recipients/offerors must collect and annually report information on sex or gender race, and ethnicity in progress reports. Refer to this Decision Tree for help determining reporting expectations for different types of studies.

Special Considerations for NIH-defined Phase III Clinical Trials

Applications & Proposals: If the proposed research includes an NIH-defined Phase III Clinical Trial , evidence must be reviewed to show whether or not clinically important differences in the intervention effect by sex or gender, race, and/or ethnicity are to be expected. The application or proposal must address plans for the valid analysis of group differences on the basis of sex or gender, race, and ethnicity unless there is clear evidence that such differences are unlikely to be seen.

Progress Reports: For projects involving NIH-defined Phase III Clinical Trials, annual Research Performance Progress Reports (RPPRs) should include a statement indicating the status of analyses of the primary outcome by sex or gender, race, and ethnicity. The results of these analyses should be included in the “Project Outcomes” section of the RPPR. See the Sample Project Outcomes page for an example.

Registering & Reporting in ClinicalTrials.gov: NIH-defined Phase III Clinical Trials that also meet the definition of an applicable clinical trial must report the results of the valid analysis of group differences in ClinicalTrials.gov. The valid analyses should be done for each primary outcome measure by sex or gender, and race and/or ethnicity. Upon study registration in ClinicalTrials.gov, outcome measures should be pre-specified by sex or gender, and race and/or ethnicity to prepare for reporting results in this stratified manner. Refer to the Guidance for Valid Analysis Reporting and NOT-OD-18-014 for additional information.

Policy Notices and Procedures

Amendment: NIH Policy and Guidelines on the Inclusion of Women and Minorities as Subjects in Clinical Research Amendment to the on the inclusion of women and minorities as subjects in clinical research. Includes requirement that recipients conducting applicable NIH-defined Phase III clinical trials ensure results of valid analyses by sex or gender, race, and/or ethnicity are submitted to ClinicalTrials.gov. November 28, 2017
NIH Policy and Guidelines on the Inclusion of Women and Minorities as Subjects in Clinical Research – Amended Updated NIH policy on the inclusion of women and minorities as subjects in clinical research, which supersedes the and . October 9, 2001
NIH Policy and Guidelines on the Inclusion of Women and Minorities as Subjects in Clinical Research Consolidated and concise summary of the on the inclusion of women and minorities in clinical research. October 9, 2001
NIH Policy on Reporting Race and Ethnicity Data: Subjects in Clinical Research Additional guidance and instruction for using the revised minimum standards for maintaining, collecting, and presenting data on race and ethnicity. August 8, 2001
Infographic that walks through the elements of the existing dataset or resource definition to help users understand whether how it applies to their research. August 2, 2024
This one-page resource highlights allowable costs for NIH grants that can be utilized to enhance inclusion through recruitment and retention activities. Allowable costs listed in the NIH Grants Policy Statement are provided with examples of inclusion-related activities. August 10, 2023
May 19, 2022
In Part 1 of this NIH All About Grants podcast miniseries, NIH’s Inclusion Policy Officer Dawn Corbett tells us how to consider inclusion plans when putting together an application.
April 20, 2022
NIH’s Inclusion Policy Officer Dawn Corbett covers inclusion plans during peer review and post-award in Part 2 of this NIH All About Grants podcast miniseries. April 20, 2022
: Recruitment and Retention Document listing resources on recruitment and retention of women, racial and ethnic minorities, and individuals across the lifespan. Resources include toolkits, articles, and more. May 9, 2022
Analyses by Sex or Gender, Race and Ethnicity for NIH-defined Phase III Clinical Trials Guidance for understanding the definition of valid analysis and links to key resources for investigators and recipeients March 8, 2022

: Including Diverse Populations in NIH-funded Clinical Research

Video presentation by the NIH Inclusion Policy Officer for the NIH Grants Conference PreCon event, Human Subjects Research: Policies, Clinical Trials, & Inclusion, in December 2022. The presentation explains NIH inclusion policies and requirements for applicants and recipients. January 27, 2023
Announcing the availability of data on sex or gender, race, and ethnicity by NIH Research, Condition, and Disease Classification (RCDC) category. April 11, 2022
Inclusion statistics by NIH RCDC category Report on the representation of participants in human subjects studies from fiscal years 2018-2021 for FY2018 projects associated with the listed Research, Condition, and Disease Categorization (RCDC) categories. April 11, 2022

Reporting the Results of Valid Analyses

The "All About Grants" podcast featuring an interview with the Inclusion Policy Officer about valid analysis reporting for the Inclusion of Women and Minorities policy. August 6, 2018
HSS overview and training information As of June 9, 2018, the Human Subjects System (HSS) replaced the Inclusion Management System (IMS). Similar to IMS, HSS is used by NIH staff, grant applicants, and recipients to manage human subjects information, including inclusion information. May 25, 2018
Valid Analysis Reporting in ClinicalTrials.gov for Applicable NIH-Defined Phase III Clinical Trials This guidance document describes the required ClinicalTrials.gov reporting of valid analysis results for applicable NIH-defined Phase III clinical trials. The guidance includes examples and recommendations for creating the NIH-required outcomes during registration and entering results for reporting. May 21, 2018
Continuing to Strengthen Inclusion Reporting on NIH-funded Phase III Trials Blog post by NIH's Deputy Director of Extramural Research, Dr. Mike Lauer describing valid analysis and the reporting requirements for applicable NIH-Defined Phase III clinical trials. January 8, 2018
Applying the Inclusion of Women and Minorities Policy A tool for understanding how to monitor inclusion based on sex or gender, race and ethnicity in research. January 3, 2018
Inclusion of Women and Minorities in Clinical Research Reports published by the Department of Health and Human Services. The data tables included in these reports provide documentation of the monitoring of inclusion with some degree of analysis. September, 2017

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Research quantifying “nociception” could help improve management of surgical pain

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A zoomed in view of a surgery in progress. Blue gowned surgeons hold scalpels and tiny scissors above an opening in the patient's dressing where skin is exposed.

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The degree to which a surgical patient’s subconscious processing of pain, or “nociception,” is properly managed by their anesthesiologist will directly affect the degree of post-operative drug side effects they’ll experience and the need for further pain management they’ll require. But pain is a subjective feeling to measure, even when patients are awake, much less when they are unconscious. 

In a new study appearing in the Proceedings of the National Academy of Sciences , MIT and Massachusetts General Hospital (MGH) researchers describe a set of statistical models that objectively quantified nociception during surgery. Ultimately, they hope to help anesthesiologists optimize drug dose and minimize post-operative pain and side effects.

The new models integrate data meticulously logged over 18,582 minutes of 101 abdominal surgeries in men and women at MGH. Led by Sandya Subramanian PhD ’21, an assistant professor at the University of California at Berkeley and the University of California at San Francisco, the researchers collected and analyzed data from five physiological sensors as patients experienced a total of 49,878 distinct “nociceptive stimuli” (such as incisions or cautery). Moreover, the team recorded what drugs were administered, and how much and when, to factor in their effects on nociception or cardiovascular measures. They then used all the data to develop a set of statistical models that performed well in retrospectively indicating the body’s response to nociceptive stimuli.

The team’s goal is to furnish such accurate, objective, and physiologically principled information in real time to anesthesiologists who currently have to rely heavily on intuition and past experience in deciding how to administer pain-control drugs during surgery. If anesthesiologists give too much, patients can experience side effects ranging from nausea to delirium. If they give too little, patients may feel excessive pain after they awaken.

“Sandya’s work has helped us establish a principled way to understand and measure nociception (unconscious pain) during general anesthesia,” says study senior author Emery N. Brown , the Edward Hood Taplin Professor of Medical Engineering and Computational Neuroscience in The Picower Institute for Learning and Memory, the Institute for Medical Engineering and Science, and the Department of Brain and Cognitive Sciences at MIT. Brown is also an anesthesiologist at MGH and a professor at Harvard Medical School. “Our next objective is to make the insights that we have gained from Sandya’s studies reliable and practical for anesthesiologists to use during surgery.”

Surgery and statistics

The research began as Subramanian’s doctoral thesis project in Brown’s lab in 2017. The best prior attempts to objectively model nociception have either relied solely on the electrocardiogram (ECG, an indirect indicator of heart-rate variability) or other systems that may incorporate more than one measurement, but were either based on lab experiments using pain stimuli that do not compare in intensity to surgical pain or were validated by statistically aggregating just a few time points across multiple patients’ surgeries, Subramanian says.

“There’s no other place to study surgical pain except for the operating room,” Subramanian says. “We wanted to not only develop the algorithms using data from surgery, but also actually validate it in the context in which we want someone to use it. If we are asking them to track moment-to-moment nociception during an individual surgery, we need to validate it in that same way.”

So she and Brown worked to advance the state of the art by collecting multi-sensor data during the whole course of actual surgeries and by accounting for the confounding effects of the drugs administered. In that way, they hoped to develop a model that could make accurate predictions that remained valid for the same patient all the way through their operation.

Part of the improvements the team achieved arose from tracking patterns of heart rate and also skin conductance. Changes in both of these physiological factors can be indications of the body’s primal “fight or flight” response to nociception or pain, but some drugs used during surgery directly affect cardiovascular state , while skin conductance (or “EDA,” electrodermal activity) remains unaffected. The study measures not only ECG but also backs it up with PPG, an optical measure of heart rate (like the oxygen sensor on a smartwatch), because ECG signals can sometimes be made noisy by all the electrical equipment buzzing away in the operating room. Similarly, Subramanian backstopped EDA measures with measures of skin temperature to ensure that changes in skin conductance from sweat were because of nociception and not simply the patient being too warm. The study also tracked respiration.

Then the authors performed statistical analyses to develop physiologically relevant indices from each of the cardiovascular and skin conductance signals. And once each index was established, further statistical analysis enabled tracking the indices together to produce models that could make accurate, principled predictions of when nociception was occurring and the body’s response.

Nailing nociception

In four versions of the model, Subramanian “supervised” them by feeding them information on when actual nociceptive stimuli occurred so that they could then learn the association between the physiological measurements and the incidence of pain-inducing events. In some of these trained versions she left out drug information and in some versions she used different statistical approaches (either “linear regression” or “random forest”). In a fifth version of the model, based on a “state space” approach, she left it unsupervised, meaning it had to learn to infer moments of nociception purely from the physiological indices. She compared all five versions of her model to one of the current industry standards, an ECG-tracking model called ANI.

Each model’s output can be visualized as a graph plotting the predicted degree of nociception over time. ANI performs just above chance but is implemented in real-time. The unsupervised model performed better than ANI, though not quite as well as the supervised models. The best performing of those was one that incorporated drug information and used a “random forest” approach. Still, the authors note, the fact that the unsupervised model performed significantly better than chance suggests that there is indeed an objectively detectable signature of the body’s nociceptive state even when looking across different patients.

“A state space framework using multisensory physiological observations is effective in uncovering this implicit nociceptive state with a consistent definition across multiple subjects,” wrote Subramanian, Brown, and their co-authors. “This is an important step toward defining a metric to track nociception without including nociceptive ‘ground truth’ information, most practical for scalability and implementation in clinical settings.”

Indeed, the next steps for the research are to increase the data sampling and to further refine the models so that they can eventually be put into practice in the operating room. That will require enabling them to predict nociception in real time, rather than in post-hoc analysis. When that advance is made, that will enable anesthesiologists or intensivists to inform their pain drug dosing judgements. Further into the future, the model could inform closed-loop systems that automatically dose drugs under the anesthesiologist’s supervision.

“Our study is an important first step toward developing objective markers to track surgical nociception,” the authors concluded. “These markers will enable objective assessment of nociception in other complex clinical settings, such as the ICU [intensive care unit], as well as catalyze future development of closed-loop control systems for nociception.”

In addition to Subramanian and Brown, the paper’s other authors are Bryan Tseng, Marcela del Carmen, Annekathryn Goodman, Douglas Dahl, and Riccardo Barbieri.

Funding from The JPB Foundation; The Picower Institute; George J. Elbaum ’59, SM ’63, PhD ’67; Mimi Jensen; Diane B. Greene SM ’78; Mendel Rosenblum; Bill Swanson; Cathy and Lou Paglia; annual donors to the Anesthesia Initiative Fund; the National Science Foundation; and an MIT Office of Graduate Education Collabmore-Rogers Fellowship supported the research.

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