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Research articles

Signatures of ambient pressure superconductivity in thin film la 3 ni 2 o 7.

• Harold Y. Hwang

A reinforced lunar dynamo recorded by Chang'e-6 farside basalt

• Rixiang Zhu

Ancient genomes reveal a deep history of treponemal disease in the Americas

• Rodrigo Barquera
• T. Lesley Sitter
• Kirsten I. Bos

Scalable production of ultraflat and ultraflexible diamond membrane

Edge-exposed exfoliation using sticky tape is shown to be a simple and reliable method for scaling up the production of ultrathin, ultraflat and ultraflexible polycrystalline diamond membranes for diverse electrical, optical, mechanical, thermal, acoustic and quantum applications.

• Jixiang Jing
• Fuqiang Sun

Nucleosome fibre topology guides transcription factor binding to enhancers

Motif grammar on nucleosome fibres acts as signpost elements, directing TF combinatorial binding to enhancers.

• Michael R. O’Dwyer
• Meir Azagury
• Abdenour Soufi

Lithocholic acid phenocopies anti-ageing effects of calorie restriction

Lithocholic acid is one of the metabolites upregulated during calorie restriction, and treatment of mice, worms and flies with this bile acid alone can reproduce the health benefits of calorie restriction.

• Sheng-Cai Lin

Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

The molecular mechanism underlying how lithocholic acid recapitulates the lifespan and healthspan benefits of calorie restriction is revealed to involve TULP3, sirtuins, v-ATPase and AMPK.

The conformational space of RNase P RNA in solution

Using a deep neural network and statistical analyses of atomic force microscopy images of individual RNA molecules enables the mapping of RNA conformational space in solution.

• Yun-Tzai Lee
• Maximilia F. S. Degenhardt
• Yun-Xing Wang

229 ThF 4 thin films for solid-state nuclear clocks

Laser excitation of the  229 Th isomer, potentially relevant for nuclear clocks, is reported in thorium fluoride thin films, which are less radioactive and amenable to integration compared with existing thorium-doped crystals.

• Chuankun Zhang
• Lars von der Wense
• Eric R. Hudson

Trimodal thermal energy storage material for renewable energy applications

A eutectic phase change material composed of boric and succinic acids demonstrates a transition at around 150 °C, with a record high reversible thermal energy uptake and thermal stability over 1,000 heating–cooling cycles.

• Saliha Saher
• Sam Johnston
• Karolina Matuszek

Diatom phytochromes integrate the underwater light spectrum to sense depth

This study demonstrates that diatoms with phytochrome photoreceptors can detect and functionally respond to the entire visible light spectrum through these sensors, enabling them to sense depth and regulate photosynthesis accordingly in marine environments.

• Carole Duchêne
• Jean-Pierre Bouly
• Marianne Jaubert

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing

A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T cells and rejuvenation associated with neural stem cells.

• Eric D. Sun
• Olivia Y. Zhou
• Anne Brunet

Terahertz field-induced metastable magnetization near criticality in FePS 3

Intense terahertz pulses are used to induce metastable magnetization with a remarkably long lifetime of more than 2.5 milliseconds in a van der Waals antiferromagnet, FePS 3 .

• Batyr Ilyas
• Tianchuang Luo

Hierarchical design of pseudosymmetric protein nanocages

A new computational method for design of pseudosymmetric self-assembling protein nanomaterials has resulted in purification of cage-like protein assemblies containing 960 subunits with a diameter of 96 nm.

• Quinton M. Dowling
• Young-Jun Park
• Neil P. King

Timely TGFβ signalling inhibition induces notochord

Through analysis of developing chick embryos and in vitro differentiation of embryonic stem cells, a study develops a method to generate a model of the human trunk with a notochord.

• Ashley R. G. Libby
• James Briscoe

Engineered extrachromosomal oncogene amplifications promote tumorigenesis

Large extrachromosomal DNAs are engineered using a CRISPR- and Cre– loxP -based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene amplifications in human cancers.

• Davide Pradella
• Minsi Zhang
• Andrea Ventura

Atmospheric rivers cause warm winters and extreme heat events

Seasons with more frequent atmospheric rivers (ARs) also have warmer than average temperatures in many mid-latitude regions, and AR events are associated with temperature anomalies of 5–10 °C above the climatological mean.

• Serena R. Scholz
• Juan M. Lora

Determining structures of RNA conformers using AFM and deep neural networks

HORNET, a method that uses unsupervised machine learning and deep neural networks to analyse atomic force microscopy data enables structural determination of RNA molecules in multiple conformations.

• Hermann F. Degenhardt

Synaptic basis of feature selectivity in hippocampal neurons

A temporally asymmetric synaptic plasticity kernel results from bidirectional modifications of synaptic weights around the induction of a place field.

• Kevin C. Gonzalez
• Adrian Negrean
• Attila Losonczy

Tidally driven remelting around 4.35 billion years ago indicates the Moon is old

Lunar rock and zircon ages were reset by a remelting event driven by the Moon’s orbital evolution, reconciling existing discrepancies in estimates for the formation time of the Moon and the crystallization time of its magma ocean.

• Francis Nimmo
• Thorsten Kleine
• Alessandro Morbidelli

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